| Low-frequency therapeutic ultrasound with varied duty cycle: effects on the ischemic brain and the inner ear. | |
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MedLine Citation:
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PMID: 20620705 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Sonothrombolysis is a promising modality for acute stroke treatment. In vitro data suggest a duty cycle dependence of sonothrombolytic efficacy of low-frequency applications. The aim of our study was to examine its impact on safety issues in a rat model of middle cerebral artery occlusion. Rats were exposed to transcranial 60-kHz ultrasound with varied duty cycles. To determine effects on the inner ear, the acoustic threshold was determined in additional healthy animals (acoustic evoked potentials). A short duty cycle (20%) resulted in significant adverse effects (ischemic volume, hemorrhage, functional outcome), which was not observed in longer duty cycle (80%). Continuous-wave insonation produced high rates of mortality and subarachnoid hemorrhage. Hearing was impaired independent of duty cycle. In conclusion, cerebral side effects may be efficiently reduced by modulation of pulsed parameters, which is in line with data on an improved efficacy with longer duty cycle. However, side effects on the auditory system were found to be independent of parameter settings. |
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Authors:
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Peter Reuter; Julia Masomi; Holger Kuntze; Ilka Fischer; Kai Helling; Clemens Sommer; Beat Alessandri; Axel Heimann; Tibo Gerriets; Juergen Marx; Oliver Kempski; Max Nedelmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 36 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1188-95 Citation Subset: IM |
Copyright Information:
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Copyright 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology, Justus Liebig University, Giessen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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