Document Detail


Low-Flow Mediated Constriction is Endothelium-Dependent: Effects of Exercise Training After Radial Artery Catheterization.
MedLine Citation:
PMID:  23011264     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: RADIAL ARTERY CATHETERIZATION IS ASSOCIATED WITH ENDOTHELIAL DENUDATION AND IMPAIRED VASODILATOR FUNCTION, WHILE POSTCATHETERIZATION EXERCISE TRAINING MAY ENHANCE ARTERY FUNCTION. THE IMPACT OF CATHETERIZATION AND SUBSEQUENT EXERCISE TRAINING ON LOW-FLOW MEDIATED VASOCONSTRICTION (L-FMC) HAS NOT PREVIOUSLY BEEN STUDIED. THE AIM OF THIS STUDY WAS TO EXAMINE WHETHER RADIAL ARTERY L-FMC IS IMPAIRED BY CATHETERIZATION AND CONSEQUENT ENDOTHELIAL DENUDATION. A FURTHER AIM WAS TO EXAMINE THE EFFECT OF LOCAL HANDGRIP EXERCISE TRAINING ON RADIAL ARTERY L-FMC AND FLOW-MEDIATED DILATION (FMD) AFTER TRANSRADIAL CATHETERIZATION.METHODS AND RESULTS: THIRTY-TWO SUBJECTS UNDERGOING TRANSRADIAL CATHETERIZATION UNDERWENT ASSESSMENT OF L-FMC AND FMD IN THE CATHETERIZED AND CONTRALATERAL RADIAL ARTERY BEFORE, AND THE DAY AFTER, CATHETERIZATION. A FURTHER 18 PATIENTS WERE RECRUITED AND RANDOMLY ASSIGNED TO EITHER A 6-WEEK HANDGRIP EXERCISE TRAINING PROGRAM (N=9) OR A NONEXERCISE CONTROL PERIOD (N=9). L-FMC WAS ATTENUATED 1 DAY POSTCATHETERIZATION IN THE CATHETERIZED ARM (2.070.84 TO 0.350.83), BUT UNCHANGED IN THE NONCATHETERIZED ARM (0.930.86 TO 0.900.92; P0.05). IN THE TRAINING STUDY, BOTH FMD AND L-FMC OF THE CATHETERIZED ARM WERE PRESERVED IN THE EXERCISE GROUP 7 WEEKS AFTER CATHETERIZATION (FMD-PRE, 6.840.79; FMD-POST, 6.851.16; L-FMC-PRE, 2.141.42; L-FMC-POST, 3.581.04%), BUT REDUCED IN THE CONTROL GROUP (FMD-PRE, 8.271.52; FMD-POST, 4.660.70; P=0.06; L-FMC-PRE, 3.261.19; L-FMC-POST, 1.341.27%; P0.05).CONCLUSIONS: Catheterization, and associated endothelial denudation, decreases L-FMC in the radial artery, suggesting that it is endothelium-dependent. Moreover, we demonstrate for the first time that exercise training has beneficial impacts on radial artery vasodilator and constrictor function.
Authors:
Ellen A Dawson; Amr Alkarmi; Dick Hj Thijssen; Sudhir Rathore; Diane E Marsman; N Timothy Cable; D Jay Wright; Daniel J Green
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-25
Journal Detail:
Title:  Circulation. Cardiovascular interventions     Volume:  -     ISSN:  1941-7632     ISO Abbreviation:  Circ Cardiovasc Interv     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101499602     Medline TA:  Circ Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
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