Document Detail


Low-dose inorganic mercury increases severity and frequency of chronic coxsackievirus-induced autoimmune myocarditis in mice.
MedLine Citation:
PMID:  21984480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mercury is a widespread environmental contaminant with neurotoxic impacts that have been observed over a range of exposures. In addition, there is increasing evidence that inorganic mercury (iHg) and organic mercury (including methyl mercury) have a range of immunotoxic effects, including immune suppression and induction of autoimmunity. In this study, we investigated the effect of iHg on a model of autoimmune heart disease in mice induced by infection with coxsackievirus B3 (CVB3). We examined the role of timing of iHg exposure on disease; in some experiments, mice were pretreated with iHg (200 μg/kg, every other day for 15 days) before disease induction with virus inoculation, and in others, they were treated with iHg after the acute (viral) phase of disease but before the development of dilated cardiomyopathy (DCM). iHg alone had no effect on heart pathology. Pretreatment with iHg before CVB3 infection significantly increased the severity of chronic myocarditis and DCM compared with control animals receiving vehicle alone. In contrast, treatment with iHg after acute myocarditis did not affect the severity of chronic disease. The increased chronic myocarditis, fibrosis, and DCM induced by iHg pretreatment were not due to increased viral replication in the heart, which was unaltered by iHg treatment. iHg pretreatment induced a macrophage infiltrate and mixed cytokine response in the heart during acute myocarditis, including significantly increased interleukin (IL)-12, IL-17, interferon-γ, and tumor necrosis factor-α levels. IL-17 levels were also significantly increased in the spleen during chronic disease. Thus, we show for the first time that low-dose Hg exposure increases chronic myocarditis and DCM in a murine model.
Authors:
Jennifer F Nyland; DeLisa Fairweather; Devon L Shirley; Sarah E Davis; Noel R Rose; Ellen K Silbergeld
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-09
Journal Detail:
Title:  Toxicological sciences : an official journal of the Society of Toxicology     Volume:  125     ISSN:  1096-0929     ISO Abbreviation:  Toxicol. Sci.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-22     Completed Date:  2012-06-06     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9805461     Medline TA:  Toxicol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-43     Citation Subset:  IM    
Affiliation:
Department of Pathology, Microbiology & Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29209, USA. jnyland@uscmed.sc.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Autoimmune Diseases / chemically induced*,  immunology,  pathology,  virology
Cardiomyopathy, Dilated / chemically induced,  immunology,  pathology,  virology
Chronic Disease
Coxsackievirus Infections / chemically induced*,  immunology,  pathology,  virology
Cytokines / immunology
Disease Models, Animal
Dose-Response Relationship, Drug
Enterovirus B, Human / growth & development*
Environmental Pollutants / toxicity*
Heart / drug effects,  virology
Male
Mercury Compounds / toxicity*
Mice
Mice, Inbred BALB C
Myocarditis / chemically induced*,  immunology,  pathology,  virology
Myocardium / immunology,  pathology
Severity of Illness Index
Spleen / immunology,  pathology
Virus Replication / drug effects
Grant Support
ID/Acronym/Agency:
K99/R00 ES015426/ES/NIEHS NIH HHS; T32 ES007141/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Environmental Pollutants; 0/Mercury Compounds
Comments/Corrections

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