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Low-Dose (1 {micro}g/kg) Clonidine Premedication and Hypotension After Carotid Artery Surgery.
MedLine Citation:
PMID:  21984028     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We investigated the role of low-dose clonidine intravenous (IV) premedication in arterial pressure variation during and after carotid endarterectomy (CEA). A total of 84 patients, American Society of Anesthesiologists (ASA) II-III, scheduled for elective CEA under general anesthesia participated in this study. The patients were divided into 2 groups: group P (n = 42) and group C (n = 42) and received N/S 0.9% (placebo) or clonidine 1 μg/kg IV, respectively, 15 minutes before induction of anesthesia. Recovery times, number of patients needed to be treated for circulatory events (hypertension, hypotension, and bradycardia), number of circulatory events per patient, and consumption of vasoactive drugs (nitroglycerine, phenylphrine, and atropine) intraoperatively and the first 6 hours postoperatively were recorded. Significantly less hypertensive episodes were observed intraoperatively, but more hypotensive episodes were observed postoperatively in patients receiving clonidine. Intravenous premedication with low-dose clonidine (1 μg/kg) seems to be effective in preventing hypertensive episodes during CEA under general anesthesia but seems to increase the incidence of hypotension postoperatively.
Authors:
Ageliki Pandazi; Periandros Karamanis; Tatiana Sidiropoulou; Paraskevi Matsota; Christos Papasideris; Dimitra Niokou; Georgia Kostopanagiotou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vascular and endovascular surgery     Volume:  45     ISSN:  1938-9116     ISO Abbreviation:  Vasc Endovascular Surg     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136421     Medline TA:  Vasc Endovascular Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-8     Citation Subset:  IM    
Affiliation:
1Second Department of Anesthesiology, University of Athens, School of Medicine, Attikon Hospital, Athens, Greece.
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