Document Detail


Low Density Lipoprotein Receptor Related Protein 1 and Abdominal Aortic Aneurysms.
MedLine Citation:
PMID:  22658609     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: A recent GWAS demonstrated an association between low density lipoprotein receptor related protein 1 (LRP1) and Abdominal Aortic Aneurysm (AAA). This review aims to identify how LRP1 may be involved in the pathogenesis of abdominal aortic aneurysm. DESIGN AND MATERIALS: A systematic review of the English language literature was undertaken in order to determine whether LRP1 and associated pathways were plausible candidates for contributing to the development and/or progression of AAA. METHODS AND RESULTS: A comprehensive literature search of MEDLINE (since 1948), Embase (since 1980) and Health and Psychological Instruments (since 1985) was conducted in January 2012 identified 50 relevant articles. These studies demonstrate that LRP1 has a diverse range of biological functions and is a plausible candidate for playing a central role in aneurysmogenesis. Importantly, LRP1 downregulates MMP (matrix metalloproteinase) activity in vascular smooth muscle cells and regulates other key pathways involved in extracellular matrix remodelling and vascular smooth muscle migration and proliferation. Crucially animal studies have shown that LRP1 depletion leads to progressive destruction of the vascular architecture and aneurysm formation. CONCLUSIONS: Published evidence suggests that LRP1 may play a key role in the development of AAA.
Authors:
J B Wild; P W Stather; N Sylvius; E Choke; R D Sayers; M J Bown
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-31
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  -     ISSN:  1532-2165     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Cardiovascular Sciences, Vascular Surgery Group, University of Leicester, Leicester LE2 7LX, UK.
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