Document Detail

Low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol ratio predicts lipid-rich coronary plaque in patients with coronary artery disease--integrated-backscatter intravascular ultrasound study.
MedLine Citation:
PMID:  20484825     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The relationship between blood lipid profile and coronary plaque tissue characteristics, and differences in the tissue characteristics between acute coronary syndrome (ACS) and chronic coronary artery disease (CCAD) are unclear. The purpose of the present study was to compare the plaque tissue characteristics in patients with ACS and CCAD and to examine the relationship between the tissue characteristics and blood lipid profile.
METHODS AND RESULTS: Integrated backscatter intravascular ultrasound (IVUS) and conventional IVUS were performed in patients with ACS (n=24) and CCAD (n=68) at the time of coronary intervention. Percent tissue volume and cross-section area of lipid pool, fibrous tissue, dense fibrous and calcification were defined in target lesions. The lipid pool area (LPA) in the ACS patients was significantly higher than in the CCAD patients (LPA, 7.0+/-3.4 vs 5.1+/-3.2 mm(2), P=0.01). In the CCAD group, LPA/non-LPA ratio tended to be higher in the ACS than in the CCAD patients (1.4+/-0.9 vs 1.1+/-0.8; P=0.08), and LDL/HDL ratio was an independent predictor for LPA/non-LPA ratio (P=0.002). In addition, LDL/HDL ratio was a useful index for the prediction of a high LPA/non-LPA ratio (area under the receiver operating characteristic curve = 0.79).
CONCLUSIONS: Elevated LDL/HDL ratio may be a positive predictor for coronary lipid-rich plaque and plaque vulnerability in patients with CCAD.
Takumi Kimura; Tomonori Itoh; Tetsuya Fusazaki; Hiroki Matsui; Shoma Sugawara; Yoshinobu Ogino; Hiroshi Endo; Ken Kobayashi; Motoyuki Nakamura
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Publication Detail:
Type:  Journal Article     Date:  2010-05-18
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-10-19     Revised Date:  2011-02-18    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1392-8     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University, Morioka, Japan.
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MeSH Terms
Acute Coronary Syndrome
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Coronary Artery Disease / blood,  diagnosis*,  pathology,  ultrasonography
Lipids / blood
Middle Aged
Predictive Value of Tests*
ROC Curve
Ultrasonography, Interventional / methods*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids
Comment In:
Circ J. 2010 Jul;74(7):1294-5   [PMID:  20558889 ]

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