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Low Density Lipoprotein Apheresis Ameliorates Interferon-γ Production in Patients With Nephrotic Syndrome.
MedLine Citation:
PMID:  22458400     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Rapid amelioration of hypercholesterolemia in nephrotic syndrome (NS) using low density lipoprotein-apheresis (LDL-A) sometimes leads to NS remission, along with improvement of impaired biodefense system; however, the mechanism of how LDL-A affects NS is still unknown. We studied IFN-γ production under IL-12 stimulation for 24 h in whole blood from 30 NS patients, 31 non-NS patients, 35 healthy volunteers and another four persistent NS patients due to refractory focal segmental glomerulonephritis and minimal change type nephrotic syndrome. We compared IFN-γ production in whole blood and peripheral blood mononuclear cells (PBMC) from persistent NS patients before and after each of 14 LDL-A procedures. Finally, we studied the effect that persistent NS patients' serum before and after LDL-A had on IFN-γ production in healthy volunteers' PBMC. Whole blood IFN-γ production was significantly lower in NS patients compared with healthy volunteers or non-NS patients. In persistent NS, after LDL-A, IFN-γ production returned to normal levels. IFN-γ production in PBMC varied greatly among these patients and did not show consistent changes after LDL-A. Healthy volunteers PBMC incubated with persistent NS patients' serum obtained after LDLA showed higher IFN-γ production than before LDL-A. IFN-γ production in peripheral blood is impaired if a patient is in a nephrotic state. LDL-A might restore suppressed PBMC function in persistent NS patients, thereby ameliorating the nephrotic state, possibly through removing interfering serum factors.
Authors:
Hitomi Miyata; Kazuko Uno; Takahiko Ono; Masatomo Yashiro; Atsushi Fukatsu; Toru Kita; Takeshi Kimura; Eri Muso
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-27
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  16     ISSN:  1744-9987     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  -    
Other Details:
Languages:  ENG     Pagination:  189-194     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis.
Affiliation:
Departments of Nephrology Cardiovascular Medicine, Graduate School of Medicine, Kyoto University Louis Pasteur Center for Medical Research Department of Nephrology, Kyoto City Hospital, Kyoto Department of Nephrology, Shimada Municipal Hospital, Shimada Department of Nephrology and Hemodialysis, Kitano Hospital, Tatsuke Kohukai Medical Research Institute, Osaka, Japan Department of Physiology, Medical Sciences, University of Otago, New Zealand.
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