Document Detail

Low DHA and plasmalogens associated with a precise PUFA-rich diet devoid of DHA.
MedLine Citation:
PMID:  20800059     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Fatty acids, being multi-functional and partially diet-dependent, are crucial for health yet optimal dietary composition remains controversial. Previous work suggests that nutritionally-dependent populations live with significant fatty acid abnormalities despite abundant polyunsaturated fatty acid intake.
DESIGN AND METHODS: An analysis of fasting plasma phospholipids, including plasmalogens, and total fatty acids was conducted on twelve tube-fed people receiving a uniform diet which meets current polyunsaturated fatty acid intake recommendations, specifically, linoleic acid as 8.1% of energy and alpha-linolenic acid as 1.3% of energy for at least two years.
RESULTS: Eicosapentaenoic- and docosahexaenoic acid-related phospholipids were low. In addition, C16:0- and C18:0-related plasmalogens, components of phospholipids, were low. Essential fatty acid deficiency as classically defined was not present.
CONCLUSIONS: Based upon extensive clinical investigations in neuro-typical people, abnormalities of these key cell-membrane components may have undesirable clinical consequences. In particular, docosahexaenoic acid sufficiency needs to be assured. Comprehensive re-evaluation of current recommendations may be necessary.
Norris R Glick; Milton H Fischer
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Publication Detail:
Type:  Journal Article     Date:  2010-08-25
Journal Detail:
Title:  Clinical biochemistry     Volume:  43     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1305-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Department of Pediatrics, University of Wisconsin, USA.
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MeSH Terms
Docosahexaenoic Acids / blood*
Middle Aged
Phospholipids / blood
Plasmalogens / blood*
Reg. No./Substance:
0/Phospholipids; 0/Plasmalogens; 25167-62-8/Docosahexaenoic Acids

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