| Low CYP1A2 activity in rural Shona children of Zimbabwe. | |
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MedLine Citation:
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PMID: 7828378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caffeine is increasingly used as a biochemical probe for liver function, in cancer epidemiology, and in pharmacogenetics, with its recognized ability to assess the activities of CYP1A2, xanthine oxidase, and N-acetyltransferase-2. The activity of these hepatic enzymes was tested in 45 Shona children from a rural area of Zimbabwe with use of caffeine as a probe. Many of these rural black children had lower indexes of CYP1A2 activity than otherwise on our extensive records; the average value (3.78 +/- 2.9) was significantly (p < 0.001) lower than that of healthy white urban children from Zimbabwe (8.86 +/- 3.36) or from Canada (7.92 +/- 1.88), or that of healthy Canadian adults (5.96 +/- 2.4). A higher CYP1A2 activity in children than in adults is usual. The low CYP1A2 activity of the children from rural Zimbabwe calls for medical studies and suggests a widespread and perhaps serious impairment of certain liver functions. Causes could be parasitic infections with Schistosoma mansoni, causing schistosomiasis, which are endemic, in addition to generally poor nutrition and frequent iodine deficiency. By contrast, the xanthine oxidase activity in rural Shona children was slightly higher than that reported for a healthy Canadian adult population. The N-acetyltransferase activities were comparable in both the rural and urban children and were also similar to those reported in a population study of healthy adult Canadians. |
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Authors:
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C M Masimirembwa; M Beke; J A Hasler; B K Tang; W Kalow |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 57 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-02-21 Completed Date: 1995-02-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 25-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Biochemistry, University of Zimbabwe, Harare. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyltransferases
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metabolism* Adolescent Adult Caffeine / metabolism, urine Canada / ethnology Child Chromatography, High Pressure Liquid Cytochrome P-450 CYP1A2 Cytochrome P-450 Enzyme System / metabolism* Female Humans Liver / enzymology* Male Oxidoreductases / metabolism* Rural Population Urban Population Xanthine Oxidase / metabolism* Zimbabwe / ethnology |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Oxidoreductases; EC 1.14.14.1/Cytochrome P-450 CYP1A2; EC 1.17.3.2/Xanthine Oxidase; EC 2.3.1.-/Acetyltransferases |
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