Document Detail

Low birth weight infants and the developmental programming of hypertension: a focus on vascular factors.
MedLine Citation:
PMID:  20494734     Owner:  NLM     Status:  MEDLINE    
Low birth weight infants, in particular those born preterm, have been shown to develop increased arterial blood pressure and hypertension at adulthood. Three main systems are involved in the developmental programming of hypertension: the kidney, the neuroendocrine system, and the vascular tree. This review focuses on vascular dysfunction and discusses clinical and experimental evidence that relates low birth weight and the risk for hypertension at adulthood. Recent studies demonstrate an impairment of vascular structure and function. Both arterial vessels, through altered arterial stiffness and endothelium-dependent vasodilation, and the capillary bed, through microvascular rarefaction, are involved in the early pathogenesis of hypertension. The key role of the endothelium, as shown by altered vasodilatation, angiogenesis, endothelial progenitor cells, and microparticle number and function, is discussed as a possible explanatory mechanism.
Isabelle Ligi; Isabelle Grandvuillemin; Virginie Andres; Françoise Dignat-George; Umberto Simeoni
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  34     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-92     Citation Subset:  IM    
Service de Médecine Néonatale, Centre Hospitalier Universitaire La Conception, Marseille, France.
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MeSH Terms
Arteries / physiopathology
Blood Vessels / physiopathology*
Endothelium, Vascular / physiopathology
Hypertension / etiology,  physiopathology*
Infant, Low Birth Weight*
Infant, Newborn
Microcirculation / physiology
Premature Birth
Stem Cells / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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