Document Detail


Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls.
MedLine Citation:
PMID:  22876849     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Following contradictory reports, the aim of this study was to apply our highly specific novel assay to delineate the relationship between vitamin D forms and Alzheimer's disease. The study incorporated patients, both untreated and treated with acetylcholinesterase inhibitors, along with controls. Patients were grouped as A: untreated (n=26) and B: treated with donepezil, rivastigmine or galantamine (n=44). The study included a control Group (C, n=35) with no cognitive impairment. Cognitive function was assessed using the MMSE. Levels of vitamin D forms were measured using liquid chromatography-mass spectrometry (LC-MS/MS) and calcium measurements were conducted using inductively coupled plasma-mass spectrometry (ICP-MS). In the cohort studied, no relationship was observed between MMSE score, calcium and any form of vitamin D. The indisputable finding is that the level of 25hydroxyvitamin D2 (25OHD2) (3.165±6.352 nmol/L, p<0.001) was significantly lower in the untreated Group (A) compared to the control and treated groups (7.932±9.196 and 12.138±15.682 nmol/L, respectively). In contrast, the levels of the primary forms, vitamin D2 and total vitamin D were the highest for the untreated group. Vitamin D levels, assessed as 25OHD are significantly lower in patients suffering from Alzheimer's disease arising from extremely low levels of 25OHD2 along with low levels of 25OHD3. Treatment with acetylcholinesterase inhibitors reverses this deficit. Further research is warranted to delineate the mode of action of acetylcholinesterase inhibitors with respect to normalising 25OHD2 levels. These observations resulted in the hypothesis that along with the common functions of vitamin D, different forms have distinct roles in health and disease.  
Authors:
I Shah; A Petroczi; N Tabet; A Klugman; M Isaac; D P Naughton
Related Documents :
16104949 - Vacuolating cytotoxin a is associated with increased thrombin generation in gastric muc...
23073059 - Patients with diabetes mellitus type 2 and hypomagnesemia may have enhanced glomerular ...
22309899 - Effect of narrowband ultraviolet b therapy on inflammatory markers and body fat composi...
10765199 - Helicobacter pylori before and after gastric reduction for morbid obesity.
22674589 - Dyselectrolytemia in acute kidney injury causing tetany and quadriparesis.
23154229 - Direct thrombin inhibitors-a case indicating benefit from 'plasmapheresis' in toxicity:...
4007399 - Gastrointestinal kaposi's sarcoma in patients with acquired immunodeficiency syndrome. ...
18186679 - Percutaneous nephrolithotomy of patients with staghorn stone and incidental purulent fl...
1880509 - Single photon emission computed tomography in patients with acute hydrocephalus or with...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-08
Journal Detail:
Title:  Current Alzheimer research     Volume:  -     ISSN:  1875-5828     ISO Abbreviation:  Curr Alzheimer Res     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208441     Medline TA:  Curr Alzheimer Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Life Sciences, Kingston University, Kingston-upon-Thames, Surrey, UK. D.Naughton@kingston.ac.uk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hydrogen Bonding in Pyridine N-Oxide/Acid Systems: Proton Transfer and Fine Details Revealed by FTIR...
Next Document:  Nanoscale Strainability of Graphene by Laser Shock Induced 3D Shaping.