Document Detail

Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production.
MedLine Citation:
PMID:  2351867     Owner:  NLM     Status:  MEDLINE    
We investigated the metabolism of very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and low density lipoprotein (LDL) apolipoprotein B (apoB) in seven patients with combined hyperlipidemia (CHL), using 125I-labeled VLDL and 131I-labeled LDL and compartmental modeling, before and during lovastatin treatment. Lovastatin therapy significantly reduced plasma levels of LDL cholesterol (142 vs 93 mg/dl, P less than 0.0005) and apoB (1328 vs 797 micrograms/ml, P less than 0.001). Before treatment, CHL patients had high production rates (PR) of LDL apoB. Three-fourths of this LDL apoB flux was derived from sources other than circulating VLDL and was, therefore, defined as "cold" LDL apoB flux. Compared to baseline, treatment with lovastatin was associated with a significant reduction in the total rate of entry of apoB-containing lipoproteins into plasma in all seven CHL subjects (40.7 vs. 25.7 mg/, P less than 0.003). This reduction was associated with a fall in total LDL apoB PR and in "cold" LDL apoB PR in six out of seven CHL subjects. VLDL apoB PR fell in five out of seven CHL subjects. Treatment with lovastatin did not significantly alter VLDL apoB conversion to LDL apoB or LDL apoB fractional catabolic rate (FCR) in CHL patients. In three patients with familial hypercholesterolemia who were studied for comparison, lovastatin treatment increased LDL apoB FCR but did not consistently alter LDL apoB PR. We conclude that lovastatin lowers LDL cholesterol and apoB concentrations in CHL patients by reducing the rate of entry of apoB-containing lipoproteins into plasma, either as VLDL or as directly secreted LDL.
Y Arad; R Ramakrishnan; H N Ginsberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of lipid research     Volume:  31     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  567-82     Citation Subset:  IM    
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032.
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MeSH Terms
Apolipoproteins B / blood*
Cholesterol, LDL / blood
Hyperlipidemias / blood,  drug therapy*
Lipoproteins / blood
Lipoproteins, HDL / blood
Lipoproteins, IDL
Lipoproteins, LDL / blood*
Lipoproteins, VLDL / blood
Lovastatin / therapeutic use*
Middle Aged
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Apolipoproteins B; 0/Cholesterol, LDL; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, IDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 75330-75-5/Lovastatin

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