Document Detail


Lovastatin inhibits HIV-1 expression in H9 human T lymphocytes cultured in cholesterol-poor medium.
MedLine Citation:
PMID:  7522603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the HMG-Coenzyme A reductase inhibitor lovastatin on HIV-1 expression and sterol synthesis have been investigated in the human H9 lymphocytic cell line. To this purpose, sterol synthesis from 14C-acetate, cell multiplication and reverse transcriptase activity have been measured in parallel at various times after cell infection by HIV-1. It was found that nine days after viral loading, lovastatin inhibited both sterol synthesis and viral multiplication as assessed by the reverse transcriptase activity. Since HIV infection has been shown to induce alterations in membrane cholesterol content, suggesting that the virus cycle may be partially dependent upon cellular cholesterol, inhibitors of cholesterol synthesis could be an interesting way of research in order to slower HIV propagation.
Authors:
J C Mazière; J C Landureau; P Giral; M Auclair; L Fall; A Lachgar; A Achour; D Zagury
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  48     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  1994  
Date Detail:
Created Date:  1994-10-25     Completed Date:  1994-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  IM; X    
Affiliation:
Laboratoire de Biochimie, Faculté de Médecine Saint-Antoine, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Cholesterol / analysis
Culture Media / analysis
HIV Reverse Transcriptase
HIV-1 / metabolism*,  physiology
Humans
Lovastatin / pharmacology*
RNA-Directed DNA Polymerase / metabolism
Sterols / biosynthesis
T-Lymphocytes / cytology,  enzymology,  microbiology*
Virus Replication / drug effects
Chemical
Reg. No./Substance:
0/Culture Media; 0/Sterols; 57-88-5/Cholesterol; 75330-75-5/Lovastatin; EC 2.7.7.49/HIV Reverse Transcriptase; EC 2.7.7.49/RNA-Directed DNA Polymerase

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