| Lovastatin inhibits HIV-1 expression in H9 human T lymphocytes cultured in cholesterol-poor medium. | |
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MedLine Citation:
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PMID: 7522603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of the HMG-Coenzyme A reductase inhibitor lovastatin on HIV-1 expression and sterol synthesis have been investigated in the human H9 lymphocytic cell line. To this purpose, sterol synthesis from 14C-acetate, cell multiplication and reverse transcriptase activity have been measured in parallel at various times after cell infection by HIV-1. It was found that nine days after viral loading, lovastatin inhibited both sterol synthesis and viral multiplication as assessed by the reverse transcriptase activity. Since HIV infection has been shown to induce alterations in membrane cholesterol content, suggesting that the virus cycle may be partially dependent upon cellular cholesterol, inhibitors of cholesterol synthesis could be an interesting way of research in order to slower HIV propagation. |
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Authors:
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J C Mazière; J C Landureau; P Giral; M Auclair; L Fall; A Lachgar; A Achour; D Zagury |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie Volume: 48 ISSN: 0753-3322 ISO Abbreviation: Biomed. Pharmacother. Publication Date: 1994 |
Date Detail:
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Created Date: 1994-10-25 Completed Date: 1994-10-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8213295 Medline TA: Biomed Pharmacother Country: FRANCE |
Other Details:
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Languages: eng Pagination: 63-7 Citation Subset: IM; X |
Affiliation:
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Laboratoire de Biochimie, Faculté de Médecine Saint-Antoine, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Cholesterol / analysis Culture Media / analysis HIV Reverse Transcriptase HIV-1 / metabolism*, physiology Humans Lovastatin / pharmacology* RNA-Directed DNA Polymerase / metabolism Sterols / biosynthesis T-Lymphocytes / cytology, enzymology, microbiology* Virus Replication / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Sterols; 57-88-5/Cholesterol; 75330-75-5/Lovastatin; EC 2.7.7.49/HIV Reverse Transcriptase; EC 2.7.7.49/RNA-Directed DNA Polymerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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