Document Detail

Lovastatin induces mitotic abnormalities in various cell lines.
MedLine Citation:
PMID:  10527548     Owner:  NLM     Status:  MEDLINE    
We examined the effects of lovastatin, a common anti-atherosclerotic drug and a blocker of the cell cycle, on the process of mitosis. It is known that lovastatin induces an arrest or a retardation of the cell cycle in many cell types not only at the G(1)phase, but also at the G(2)/M transition. After 24-48 h incubation of epithelial PtK(2), T24, HeLa cells and fibroblastic L929 cells in the presence of 1. 0-60.0 microm lovastatin, diverse mitotic perturbations have been observed. The most noteworthy phenomena recorded were prometaphase retardation and chromosome lagging during metaphase and anaphase. After the recovery in lovastatin-free media, the cells continued mitosis without any disturbances. Mevalonic acid prevented the effects of lovastatin. We conclude that the effects were specific for lovastatin-induced inhibition of mevalonic acid synthesis. Immunofluorescence studies with anticentromeric antibodies suggested that one of the possible causes of the lovastatin-induced mitotic disorder could be an interference with the development and function of the centromeres.
J Lamprecht; C Wójcik; M Jakóbisiak; M Stoehr; D Schrorter; N Paweletz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  23     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  1999  
Date Detail:
Created Date:  2000-04-04     Completed Date:  2000-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  51-60     Citation Subset:  IM    
Department of Histology and Embryology, Medical University of Warsaw, Chalubińskiego 5, Warsaw, 02-004, Poland.
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MeSH Terms
Anticholesteremic Agents / pharmacology*
Cell Line
Centromere / drug effects
Fluorescent Antibody Technique
Hela Cells
Lovastatin / pharmacology*
Mevalonic Acid / metabolism
Mitosis / drug effects*
Reg. No./Substance:
0/Anticholesteremic Agents; 150-97-0/Mevalonic Acid; 75330-75-5/Lovastatin

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