| Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells. | |
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MedLine Citation:
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PMID: 16316623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lovastatin inhibits a 3-hydroxy 3-methylglutaryl coenzyme A reductase and prevents the synthesis of cholesterol precursors, such as farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), responsible for important cell signaling in cell proliferation and migration. Recently, the anti-cancer effect of lovastatin has been suggested in various tumor types. In this study, we showed that a low dose lovastatin induced senescence and G1 cell cycle arrest in human prostate cancer cells. Addition of GGPP or mevalonate, but not FPP, prevented the lovastatin-induced G1 phase cell cycle arrest and cell senescence. We found that constitutively active RhoA (caRhoA) reversed lovastatin-induced senescence in caRhoA-transfected PC-3 cells. Thus, we postulate that modulation of RhoA may be critical in lovastatin-induced senescence in PC-3 cells. |
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Authors:
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Jeeyun Lee; Inkyoung Lee; Chaehwa Park; Won Ki Kang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 339 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-13 Completed Date: 2006-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 748-54 Citation Subset: IM |
Affiliation:
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Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage Cell Aging / drug effects* Cell Cycle / drug effects* Cell Line, Tumor Dose-Response Relationship, Drug Gene Expression Regulation, Neoplastic / drug effects Humans Lovastatin / administration & dosage* Male Prostatic Neoplasms / metabolism*, pathology* rhoA GTP-Binding Protein / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 75330-75-5/Lovastatin; EC 3.6.5.2/rhoA GTP-Binding Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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