Document Detail


Loss of secondary esophageal peristalsis is not a contributory pathogenetic factor in posterior laryngitis.
MedLine Citation:
PMID:  11219523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secondary esophageal peristalsis helps prevent the entry of gastric acid into the pharynx by clearing the refluxed gastric contents back into the stomach. Because the loss of this mechanism may contribute to the pathogenesis of reflux-induced laryngeal disorders, our aim was to study the frequency of stimulation and parameters of secondary esophageal peristalsis in patients with posterior laryngitis (PL). We studied 14 patients (45 +/- 5 years) with PL documented by videolaryngoscopy and 11 healthy controls (46 +/- 6 years). The upper esophageal sphincter (UES) pressure was monitored by a sleeve assembly incorporating an injection port 5 cm distal to the sleeve. The esophageal body and lower esophageal sphincter (LES) pressures were measured by an LES sleeve assembly. Primary esophageal peristalsis was induced by 5-mL water swallows. Secondary esophageal peristalsis was induced by abrupt injection of volumes of air, incrementally increased by 5 mL, into the esophagus. Secondary esophageal peristalsis could not be elicited by injection of any volume (up to 60 mL) in 3 PL patients and 2 controls. These 5 subjects had normal primary peristalsis. The threshold volume of air required to stimulate secondary esophageal peristalsis in PL patients (median, 15 mL) was similar to that of controls (median, 10 mL). The parameters of the secondary esophageal peristaltic pressure wave were similar in both groups, and in both groups, they were similar to those of primary peristalsis. The UES response to the injection of the threshold volume that induced secondary esophageal peristalsis in PL patients was contraction in 58% of the trials, partial relaxation in 3%, and no response in 39%. The findings were similar to those in the controls. The LES response to injection of the threshold volume was complete relaxation in both the PL patients and the controls. We conclude that the integrity of secondary esophageal peristalsis is preserved in PL patients.
Authors:
S O Ulualp; C Gu; R J Toohill; R Shaker
Related Documents :
8473093 - Esophago-rectal reflex. description and clinical significance.
6500363 - Endoscopic pancreatic and biliary manometry in pancreatic, biliary, and papillary disea...
23977363 - α-msh analogue attenuates blood pressure elevation in doca-salt hypertensive mice.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  110     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-21     Completed Date:  2001-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-7     Citation Subset:  AIM; IM    
Affiliation:
Medical College of Wisconsin Dysphagia Institute, Department of Otolaryngology and Human Communication Sciences, Medical College of Wisconsin, Milwaukee, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Case-Control Studies
Deglutition
Female
Gastroesophageal Reflux / complications*,  diagnosis,  physiopathology*
Humans
Laryngitis / etiology*
Laryngoscopy
Male
Middle Aged
Monitoring, Physiologic
Peristalsis*
Pressure
Risk Factors
Videotape Recording
Grant Support
ID/Acronym/Agency:
R01 DK25731/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Correlation between microbiology and previous sinus surgery in patients with chronic maxillary sinus...
Next Document:  Thyroarytenoid muscle: functional subunits based on morphology and muscle fiber typing in cats.