Document Detail


Loss of reliable temporal structure in event-related averaging of naturalistic stimuli.
MedLine Citation:
PMID:  22813575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To separate neural signals from noise, brain responses measured in neuroimaging are routinely averaged across space and time. However, such procedures may obscure some properties of neural activity. Recently, multi-voxel pattern analysis methods have demonstrated that patterns of activity across voxels contain valuable information that is concealed by spatial averaging. Here we show that temporal patterns of neural activity contain information that can discriminate different stimuli, even within brain regions that show no net activation to that stimulus class. Furthermore, we find that in many brain regions, responses to natural stimuli are highly context dependent. In such cases, prototypical event-related responses do not even exist for individual stimuli, so that averaging responses to the same stimulus within different contexts may worsen the effective signal-to-noise. As a result, analysis of the temporal structures of single events can reveal aspects of neural dynamics which cannot be detected using standard event-related averaging methods.
Authors:
Aya Ben-Yakov; Christopher J Honey; Yulia Lerner; Uri Hasson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-14
Journal Detail:
Title:  NeuroImage     Volume:  63     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-29     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  501-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms*
Artifacts*
Auditory Perception / physiology*
Brain / physiology*
Data Interpretation, Statistical*
Evoked Potentials, Auditory / physiology*
Female
Humans
Male
Reproducibility of Results
Sensitivity and Specificity
Young Adult
Grant Support
ID/Acronym/Agency:
R01 MH094480/MH/NIMH NIH HHS; R01MH094480/MH/NIMH NIH HHS; R21-DA024423/DA/NIDA NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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