| Loss of proviral DNA sequences in a revertant of Kirsten sarcoma virus-transformed murine fibroblasts. | |
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MedLine Citation:
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PMID: 227995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A previously described revertant cell line (K-BALB SR1212), derived as a single cell clone from a clonal line of murine fibroblasts (K-BALB) transformed by a nonproductive infection with the Kirsten strain of murine sarcoma virus, has normal morphology and growth kinetics and, unlike the transformed parent cell line, lacks a sarcoma virus that can be rescued. We report here that this reversion correlates with low to undetectable levels of expression of cellular Ki-MSV-specific RNA and a reduction of proviral sequences in the cell DNA to a level equivalent to that found in the uninfected BALB cells with a normal phenotype. The data indicate that phenotypic reversion has occurred as a consequence of the loss of part or all of the sarcoma provirus, either by chromosomal rearrangement or provirus excision. |
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Authors:
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C D Trainor; M S Reitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of general virology Volume: 44 ISSN: 0022-1317 ISO Abbreviation: J. Gen. Virol. Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1980-01-24 Completed Date: 1980-01-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 245-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Clone Cells DNA / analysis* DNA, Viral / analysis* Fibroblasts Kirsten murine sarcoma virus / analysis* Mice Mice, Inbred BALB C Nucleic Acid Hybridization RNA / analysis* RNA, Viral / analysis* Sarcoma Viruses, Murine / analysis* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/RNA, Viral; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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