Document Detail

Loss of protective immunity to polio, diphtheria and Haemophilus influenzae type b after allogeneic bone marrow transplantation.
MedLine Citation:
PMID:  8703445     Owner:  NLM     Status:  MEDLINE    
Immunity to poliovirus, diphtheria and Haemophilus influenzae type b (Hib) was studied in 16 adult recipients of a bone marrow transplant from an HLA-identical sibling donor in order to evaluate the need for revaccinations. T-cell depletion was not done in any case. The donors and patients were studied before bone marrow transplantation (BMT) and the patients 1, 3, 6, and 12 months later. Prior to the BMT 10 of 11 patients were immune (titre > or = 4) to all vaccine poliovirus types by a standard microneutralization assay. At 12 months after BMT only two of seven patients were immune to all vaccine types, and none had immunity against an antigenically altered poliovirus type 3 strain Finland. The geometric means of antibody titres against poliovirus types 1, 2, and 3 strain Saukett and strain Finland declined gradually after 1 month postgrafting, being 4.4, 5.4, 3.3, and 1.3 respectively at 12 months after BMT. At 1 year 6 of 11 patients had immunity against diphtheria by a toxin neutralization method, but the antitoxin geometric mean level had decreased to a barely protective level, 0.01 IU/ml. The geometric mean Hib antibody concentration decreased during the first 6 months after BMT and thereafter increased slightly. A significant proportion of BMT recipients lose their protection against polio, diphtheria and Hib, and revaccinations are necessary.
T Parkkali; T Ruutu; M Stenvik; T Kuronen; H Käyhty; T Hovi; R M Olander; L Volin; P Ruutu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  104     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-09-09     Completed Date:  1996-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  383-8     Citation Subset:  IM    
Department of Medicine, Helsinki University Central Hospital, Finland.
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MeSH Terms
Bone Marrow Transplantation / adverse effects*
Corynebacterium diphtheriae / immunology
Diphtheria / prevention & control*
Disease Outbreaks / prevention & control
Haemophilus Infections / prevention & control*
Haemophilus influenzae / immunology
Immunization Schedule
Poliomyelitis / prevention & control*
Poliovirus / immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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