| Loss of olfactory function after exposure to barbituric acid. | |
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MedLine Citation:
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PMID: 19423247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this case report a patient with anosmia due to occupational exposure to barbituric acid will be presented. Occupational exposure to high concentrations of barbituric acid resulted in bloody nasal secretion and nasal itching with immediate onset following exposure. After several days of exposure, a progressive loss of smell resulted in anosmia. Psychophysical and electrophysiological assessment of olfactory function with the "Sniffin Sticks" test and event-related potentials based on air dilution olfactometry confirmed the patients' reports. After 2 years no recovery is remarked. Toxic anosmia has repeatedly been described due to exposure to chemicals, although barbituric acid has not been reported to be the cause of anosmia to date. Awareness of clinicians to toxic anosmia and the report of those cases appear to be mandatory to reduce occupational risks. |
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Authors:
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C Heiser; K Grupp; K H?rmann; B A Stuck |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-05-06 |
Journal Detail:
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Title: Auris, nasus, larynx Volume: 37 ISSN: 1879-1476 ISO Abbreviation: Auris Nasus Larynx Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708170 Medline TA: Auris Nasus Larynx Country: Netherlands |
Other Details:
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Languages: eng Pagination: 103-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Clemens.Heiser@umm.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Barbiturates
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adverse effects* Disease Progression Electrophysiology / instrumentation Evoked Potentials / physiology Humans Male Middle Aged Occupational Diseases / prevention & control Occupational Exposure / prevention & control Olfaction Disorders / chemically induced*, diagnosis, physiopathology Olfactory Bulb / drug effects, physiopathology Psychophysics Risk Factors Severity of Illness Index Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Barbiturates; 67-52-7/barbituric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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