Document Detail

Loss of olfactory function after exposure to barbituric acid.
MedLine Citation:
PMID:  19423247     Owner:  NLM     Status:  MEDLINE    
In this case report a patient with anosmia due to occupational exposure to barbituric acid will be presented. Occupational exposure to high concentrations of barbituric acid resulted in bloody nasal secretion and nasal itching with immediate onset following exposure. After several days of exposure, a progressive loss of smell resulted in anosmia. Psychophysical and electrophysiological assessment of olfactory function with the "Sniffin Sticks" test and event-related potentials based on air dilution olfactometry confirmed the patients' reports. After 2 years no recovery is remarked. Toxic anosmia has repeatedly been described due to exposure to chemicals, although barbituric acid has not been reported to be the cause of anosmia to date. Awareness of clinicians to toxic anosmia and the report of those cases appear to be mandatory to reduce occupational risks.
C Heiser; K Grupp; K H?rmann; B A Stuck
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-05-06
Journal Detail:
Title:  Auris, nasus, larynx     Volume:  37     ISSN:  1879-1476     ISO Abbreviation:  Auris Nasus Larynx     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708170     Medline TA:  Auris Nasus Larynx     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  103-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
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MeSH Terms
Barbiturates / adverse effects*
Disease Progression
Electrophysiology / instrumentation
Evoked Potentials / physiology
Middle Aged
Occupational Diseases / prevention & control
Occupational Exposure / prevention & control
Olfaction Disorders / chemically induced*,  diagnosis,  physiopathology
Olfactory Bulb / drug effects,  physiopathology
Risk Factors
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Barbiturates; 67-52-7/barbituric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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