Document Detail

Loss of nuclear BRCA1 localization in breast carcinoma is age dependent.
MedLine Citation:
PMID:  11889597     Owner:  NLM     Status:  MEDLINE    
Abstract. Patients carrying a germ line mutation in the BRCA1 gene are predisposed to breast cancer. Somatic BRCA1 mutations were almost never reported in sporadic breast tumors, but several authors have described a decrease in BRCA1 mRNA and protein. In order to further investigate the possible role of BRCA1 in sporadic breast cancer, an improved immunohistochemical protocol was developed and applied on tissue sections obtained from 102 cancer patients belonging to two nonoverlapping age groups (less than 40 and more than 60 years). Based on the obtained BRCA1 specific nuclear staining we could distinguish two categories of breast cancer. The staining was present in almost all the nuclei of the normal and the cancer cells in about 50% of young (less than 40 years old) as well as older patients (more than 60 years old). Thus, BRCA1 does not seem to be involved in the genesis of these cancers. In the second category of patients, either a fraction of, or all tumor cells showed no nuclear staining. In this category, no nuclear BRCA1 staining could be observed in the tumor cells of 14 (27%) young and 3 (6%) older patients. Among six young patients bearing a breast tumor showing no BRCA1 nuclear staining at all, one was found to carry a BRCA1 germline mutation. Taken together, our results suggest that the molecular pathway in which the BRCA1 protein participates is disturbed in about 50% of sporadic breast cancer, this effect being more pronounced in tumors of young patients.
Marika Bogdani; E Teugels; J De Grève; C Bourgain; B Neyns; M Pipeleers-Marichal
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Publication Detail:
Type:  Journal Article     Date:  2001-12-04
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  440     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-12     Completed Date:  2002-05-15     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  274-9     Citation Subset:  IM    
Department of Pathology, Academic Hospital, Free University of Brussels (VUB), Laarbeeklaan, 101, 1090, Belgium.
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MeSH Terms
Adenocarcinoma / genetics,  metabolism*,  pathology
Aged, 80 and over
Aging / physiology*
BRCA1 Protein / biosynthesis*,  genetics
Breast Neoplasms / genetics,  metabolism*,  pathology
Carcinoma in Situ / genetics,  metabolism*,  pathology
Cell Nucleus / metabolism,  pathology
Fluorescent Antibody Technique, Indirect
Middle Aged
RNA, Messenger / metabolism
RNA, Neoplasm / analysis
Retrospective Studies
Reg. No./Substance:
0/BRCA1 Protein; 0/RNA, Messenger; 0/RNA, Neoplasm

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