Document Detail

Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome.
MedLine Citation:
PMID:  7552377     Owner:  NLM     Status:  MEDLINE    
Maternal cigarette smoking has a high correlation with sudden Infant Death Syndrome, a condition in which cardiorespiratory failure occurs during an hypoxic episode, as in sleep apnea. Pregnant rats were given nicotine infusions of 2 or 6 mg/kg/day throughout gestation, regimens that produce plasma nicotine levels spanning the range in smokers. The day after birth, animals in the high dose group displayed excessive mortality during hypoxic challenge. These animals were found to be deficient in an essential response component, namely adrenomedullary catecholamine release that is required to maintain neonatal cardiac rhythm during hypoxia; the defect was in adrenal cell function rather than in altered innervation or nicotinic receptor desensitization. We also examined brainstem and forebrain noradrenergic mechanisms that are involved in neonatal respiratory control. The nicotine group showed suppressed spontaneous neuronal activity, but were hyperresponsive to hypoxia. As these projections are inhibitory for respiration, the nicotine-induced sensitization would be expected to contribute to respiratory arrest during hypoxia. Prenatal nicotine exposure may thus provide a useful animal model with which to study the physiological mechanisms that underlie Sudden Infant Death Syndrome, while at the same time providing a biological explanation for the association of the syndrome with smoking.
T A Slotkin; S E Lappi; E C McCook; B A Lorber; F J Seidler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research bulletin     Volume:  38     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-14     Completed Date:  1995-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Adrenal Glands / metabolism
Animals, Newborn / physiology
Brain Chemistry / drug effects
Catecholamines / metabolism
Hypoxia, Brain / metabolism,  physiopathology*
Infant, Newborn
Myocardium / metabolism
Nicotine / toxicity*
Nicotinic Agonists / toxicity*
Norepinephrine / metabolism
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Receptors, Adrenergic / metabolism
Sudden Infant Death / etiology*
Reg. No./Substance:
0/Catecholamines; 0/Nicotinic Agonists; 0/Receptors, Adrenergic; 51-41-2/Norepinephrine; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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