Document Detail


Loss of morphine hyperphagia following neonatal monosodium glutamate treatment in rats.
MedLine Citation:
PMID:  3951319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Morphine stimulates food intake in mildly-deprived and nondeprived rats. Neonatal administration of monosodium glutamate (MSG) destroys the medial-basal hypothalamus and other circumventricular organs, including cells containing beta-endorphin that project to other hypothalamic nuclei proposed in the modulation of morphine hyperphagia. Food intake of MSG-treated and control rats were assessed following vehicle and morphine (1.0-5.0 mg/kg, sc) treatment in a mild (5h) food deprivation paradigm. Morphine hyperphagia was found to be absent in MSG-treated rats, although they responded normally to mild deprivation following vehicle treatment. These results add to the types of ingestive deficits observed in the MSG-treated rat, and suggest that the circumventricular system in general, and opioid medial-basal hypothalamic cells in particular may be implicated in morphine hyperphagia.
Authors:
R J Bodnar; P E Mann; M T Romero; L S Truesdell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  38     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-15     Completed Date:  1986-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  947-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arcuate Nucleus / drug effects,  pathology
Eating / drug effects*
Female
Food Deprivation
Glutamates / pharmacology*
Hypothalamus, Middle / drug effects,  physiology
Median Eminence / drug effects,  pathology
Morphine / pharmacology*
Necrosis
Rats
Sodium Glutamate / pharmacology*
Grant Support
ID/Acronym/Agency:
RR 07064/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glutamates; 142-47-2/Sodium Glutamate; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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