Document Detail

Loss of morphine hyperphagia following neonatal monosodium glutamate treatment in rats.
MedLine Citation:
PMID:  3951319     Owner:  NLM     Status:  MEDLINE    
Morphine stimulates food intake in mildly-deprived and nondeprived rats. Neonatal administration of monosodium glutamate (MSG) destroys the medial-basal hypothalamus and other circumventricular organs, including cells containing beta-endorphin that project to other hypothalamic nuclei proposed in the modulation of morphine hyperphagia. Food intake of MSG-treated and control rats were assessed following vehicle and morphine (1.0-5.0 mg/kg, sc) treatment in a mild (5h) food deprivation paradigm. Morphine hyperphagia was found to be absent in MSG-treated rats, although they responded normally to mild deprivation following vehicle treatment. These results add to the types of ingestive deficits observed in the MSG-treated rat, and suggest that the circumventricular system in general, and opioid medial-basal hypothalamic cells in particular may be implicated in morphine hyperphagia.
R J Bodnar; P E Mann; M T Romero; L S Truesdell
Related Documents :
12534829 - Reproduction of the raccoon dog (nyctereutes procyonoides) after feeding or food depriv...
19876009 - Neutral aminopeptidase and dipeptidyl peptidase iv activities in plasma of monosodium g...
9972869 - Prolongation of life in an experimental model of aging in drosophila melanogaster.
20969849 - Differential effects of chronic naltrexone treatment on food intake patterns and body w...
15264229 - Food deprivation decreases responsiveness of ventromedial hypothalamic neurons to melan...
3620959 - Neurotransmitter alterations associated with feeding and satiety.
4872449 - Feeding and core temperature in albino rats: changes induced by preoptic heating and co...
17438759 - Vertical and temporal distribution of persistent organic pollutants in toronto. 1. orga...
10499479 - Dietary analysis in symptomatic patients with coeliac disease on a gluten-free diet: th...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  38     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-15     Completed Date:  1986-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  947-50     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arcuate Nucleus / drug effects,  pathology
Eating / drug effects*
Food Deprivation
Glutamates / pharmacology*
Hypothalamus, Middle / drug effects,  physiology
Median Eminence / drug effects,  pathology
Morphine / pharmacology*
Sodium Glutamate / pharmacology*
Grant Support
Reg. No./Substance:
0/Glutamates; 142-47-2/Sodium Glutamate; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modulation of bovine adrenal gland secretion by etorphine and diprenorphine.
Next Document:  Effect of ipriflavone on glucocorticoid-induced osteoporosis in rats.