| Loss of morphine hyperphagia following neonatal monosodium glutamate treatment in rats. | |
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MedLine Citation:
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PMID: 3951319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphine stimulates food intake in mildly-deprived and nondeprived rats. Neonatal administration of monosodium glutamate (MSG) destroys the medial-basal hypothalamus and other circumventricular organs, including cells containing beta-endorphin that project to other hypothalamic nuclei proposed in the modulation of morphine hyperphagia. Food intake of MSG-treated and control rats were assessed following vehicle and morphine (1.0-5.0 mg/kg, sc) treatment in a mild (5h) food deprivation paradigm. Morphine hyperphagia was found to be absent in MSG-treated rats, although they responded normally to mild deprivation following vehicle treatment. These results add to the types of ingestive deficits observed in the MSG-treated rat, and suggest that the circumventricular system in general, and opioid medial-basal hypothalamic cells in particular may be implicated in morphine hyperphagia. |
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Authors:
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R J Bodnar; P E Mann; M T Romero; L S Truesdell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 38 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-04-15 Completed Date: 1986-04-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 947-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arcuate Nucleus / drug effects, pathology Eating / drug effects* Female Food Deprivation Glutamates / pharmacology* Hypothalamus, Middle / drug effects, physiology Median Eminence / drug effects, pathology Morphine / pharmacology* Necrosis Rats Sodium Glutamate / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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RR 07064/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 142-47-2/Sodium Glutamate; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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