Document Detail

Loss of morphine hyperphagia following neonatal monosodium glutamate treatment in rats.
MedLine Citation:
PMID:  3951319     Owner:  NLM     Status:  MEDLINE    
Morphine stimulates food intake in mildly-deprived and nondeprived rats. Neonatal administration of monosodium glutamate (MSG) destroys the medial-basal hypothalamus and other circumventricular organs, including cells containing beta-endorphin that project to other hypothalamic nuclei proposed in the modulation of morphine hyperphagia. Food intake of MSG-treated and control rats were assessed following vehicle and morphine (1.0-5.0 mg/kg, sc) treatment in a mild (5h) food deprivation paradigm. Morphine hyperphagia was found to be absent in MSG-treated rats, although they responded normally to mild deprivation following vehicle treatment. These results add to the types of ingestive deficits observed in the MSG-treated rat, and suggest that the circumventricular system in general, and opioid medial-basal hypothalamic cells in particular may be implicated in morphine hyperphagia.
R J Bodnar; P E Mann; M T Romero; L S Truesdell
Related Documents :
15264229 - Food deprivation decreases responsiveness of ventromedial hypothalamic neurons to melan...
15898479 - The effects of establishing operations on preferences for tangible items.
14681719 - Mild dehydration: a risk factor of constipation?
18604269 - Sensory perception of food and insulin-like signals influence seizure susceptibility.
3951319 - Loss of morphine hyperphagia following neonatal monosodium glutamate treatment in rats.
20434059 - The role of sensitivity to reward and impulsivity in food-cue reactivity.
3892379 - Food intake control in birds.
3680729 - Relationships of first lactation milk and type traits to cow survival and a sire index ...
15969679 - A framework for measuring costs to society of ige-mediated food allergy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  38     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-15     Completed Date:  1986-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  947-50     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arcuate Nucleus / drug effects,  pathology
Eating / drug effects*
Food Deprivation
Glutamates / pharmacology*
Hypothalamus, Middle / drug effects,  physiology
Median Eminence / drug effects,  pathology
Morphine / pharmacology*
Sodium Glutamate / pharmacology*
Grant Support
Reg. No./Substance:
0/Glutamates; 142-47-2/Sodium Glutamate; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modulation of bovine adrenal gland secretion by etorphine and diprenorphine.
Next Document:  Effect of ipriflavone on glucocorticoid-induced osteoporosis in rats.