Document Detail

Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants.
MedLine Citation:
PMID:  16857404     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Human herpes virus-7 (HHV-7) infection is widespread throughout the world. No data are available in Argentina about loss of maternally-derived HHV-7 immunity and natural infection. OBJECTIVES: The objective of this study was to characterize the time when children lose maternal antibodies and become susceptible to natural infection. METHODS: Sera from 39 pregnant women and 207 infants between 2 and 29 months of age were tested. Determination of IgG antibodies was made by indirect immunofluorescence. RESULTS: The seropositive ratio fell in the 2-4 month group (15% seropositive) and increased between 5 months (47% seropositive) and 23 months (67%). Geometric mean titers (GMT) of the infants aged 2-4 months (GMT = 60) were statistically different (p < 0.0001, Student's t-test) to those from the group of pregnant women (GMT = 83) and those from the other infant groups (p < 0.001, least significant difference (LSD) test). The GMT of the groups between 5 and 23 months did not show significant differences whereas those of infants between 24 and 29 months (GMT = 179, 79% seropositive) were different from all the groups studied (p < 0.0001, LSD test). CONCLUSIONS: This study shows a significant association between the loss of passive HHV-7 antibody and age. HHV-7 enters the susceptible population at 5 months, leading to the high prevalence of antibodies between 24 and 29 months of age. This study also shows that natural infection by HHV-7 in children during their first years of life follows the infection pattern found in developing countries.
Dolores Bustos; Patricia Biganzoli; Silvia Ethel Carricart; Leonardo Ferreyra; Silvia Viviana Nates; Jorge Victorio Pavan
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Publication Detail:
Type:  Journal Article     Date:  2006-07-20
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  10     ISSN:  1201-9712     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  354-7     Citation Subset:  IM    
Virology Institute Dr J. Vanella, School of Medical Sciences, National University of Córdoba, Córdoba, Argentina.
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MeSH Terms
Antibodies, Viral / blood
Argentina / epidemiology
Child, Preschool
Fluorescent Antibody Technique, Indirect / methods
Herpesvirus 7, Human / immunology*
Immunity, Maternally-Acquired / immunology*
Roseolovirus Infections / epidemiology,  immunology*
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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