Document Detail


Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal loss.
MedLine Citation:
PMID:  23145320     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null mice (Anxa5-KO). These changes occurred even when only the mother was Anxa5-KO. A small amount of placental fibrin deposition was observed in the decidual tissues, but did not noticeably differ between wild-type and Anxa5-KO mice. However, immunoreactivity for integrin beta 3/CD61, a platelet marker, was demonstrated within thrombi in the arterial canals only in Anxa5-KO mothers. Subcutaneous administration of the anticoagulant heparin to pregnant Anxa5-KO mice significantly reduced pregnancy loss, suggesting that maternal Anxa5 is crucial for maintaining intact placental circulation. Hence, the presence of maternal Anxa5 minimises the risk of thrombosis in the placental circulation and reduces the risk of foetal loss.
Authors:
Hiroshi Ueki; Tomona Mizushina; Titaree Laoharatchatathanin; Ryota Terashima; Yasuhiro Nishimura; Duangjai Rieanrakwong; Tomohiro Yonezawa; Shiro Kurusu; Yoshihisa Hasegawa; Bent Brachvogel; Ernst Pöschl; Mitsumori Kawaminami
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-09
Journal Detail:
Title:  Scientific reports     Volume:  2     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-05-23     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  827     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous* / genetics,  pathology
Animals
Annexin A5* / genetics,  metabolism
Anticoagulants / administration & dosage
Antiphospholipid Syndrome / genetics,  pathology
Blood Platelets / metabolism
Female
Heparin / administration & dosage
Humans
Integrin beta3 / metabolism
Mice
Placenta* / blood supply,  metabolism
Placental Circulation / genetics*
Pregnancy
Thrombosis / genetics*
Grant Support
ID/Acronym/Agency:
G0802553//Medical Research Council
Chemical
Reg. No./Substance:
0/Annexin A5; 0/Anticoagulants; 0/Integrin beta3; 9005-49-6/Heparin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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