| Loss of maternal annexin a5 increases the likelihood of placental platelet thrombosis and foetal loss. | |
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MedLine Citation:
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PMID: 23145320 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null mice (Anxa5-KO). These changes occurred even when only the mother was Anxa5-KO. A small amount of placental fibrin deposition was observed in the decidual tissues, but did not noticeably differ between wild-type and Anxa5-KO mice. However, immunoreactivity for integrin beta 3/CD61, a platelet marker, was demonstrated within thrombi in the arterial canals only in Anxa5-KO mothers. Subcutaneous administration of the anticoagulant heparin to pregnant Anxa5-KO mice significantly reduced pregnancy loss, suggesting that maternal Anxa5 is crucial for maintaining intact placental circulation. Hence, the presence of maternal Anxa5 minimises the risk of thrombosis in the placental circulation and reduces the risk of foetal loss. |
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Authors:
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Hiroshi Ueki; Tomona Mizushina; Titaree Laoharatchatathanin; Ryota Terashima; Yasuhiro Nishimura; Duangjai Rieanrakwong; Tomohiro Yonezawa; Shiro Kurusu; Yoshihisa Hasegawa; Bent Brachvogel; Ernst Pöschl; Mitsumori Kawaminami |
Publication Detail:
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Type: Journal Article Date: 2012-11-09 |
Journal Detail:
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Title: Scientific reports Volume: 2 ISSN: 2045-2322 ISO Abbreviation: Sci Rep Publication Date: 2012 |
Date Detail:
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Created Date: 2012-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101563288 Medline TA: Sci Rep Country: England |
Other Details:
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Languages: eng Pagination: 827 Citation Subset: IM |
Affiliation:
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Laboratory of Veterinary Physiology, School of Veterinary Medicine, Kitasato University , Towada, Aomori 034-8628, Japan ; Current address: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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