Document Detail


Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control.
MedLine Citation:
PMID:  19959345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Movement disturbances are often overlooked consequences of chronic cocaine abuse. The purpose of this study was to systematically investigate sensorimotor performance in chronic cocaine users and characterize changes in brain activity among movement-related regions of interest (ROIs) in these users. Functional magnetic resonance imaging data were collected from 14 chronic cocaine users and 15 age- and gender-matched controls. All participants performed a sequential finger-tapping task with their dominant, right hand interleaved with blocks of rest. For each participant, percent signal change from rest was calculated for seven movement-related ROIs in both the left and right hemisphere. Cocaine users had significantly longer reaction times and higher error rates than controls. Whereas the controls used a left-sided network of motor-related brain areas to perform the task, cocaine users activated a less lateralized pattern of brain activity. Users had significantly more activity in the ipsilateral (right) motor and premotor cortical areas, anterior cingulate cortex and the putamen than controls. These data demonstrate that, in addition to the cognitive and affective consequences of chronic cocaine abuse, there are also pronounced alterations in sensorimotor control in these individuals, which are associated with functional alterations throughout movement-related neural networks.
Authors:
Colleen A Hanlon; Michael J Wesley; Alicia J Roth; Mack D Miller; Linda J Porrino
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Psychiatry research     Volume:  181     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-04-20     Revised Date:  2013-11-15    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  15-23     Citation Subset:  IM    
Affiliation:
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / blood supply,  physiopathology*
Brain Mapping
Chronic Disease
Cocaine-Related Disorders / physiopathology*
Female
Fingers
Functional Laterality*
Humans
Magnetic Resonance Imaging
Male
Motor Activity / physiology*
Neuropsychological Tests
Oxygen / blood
Psychomotor Performance / physiology*
Reaction Time
Touch Perception / physiology
Grant Support
ID/Acronym/Agency:
DA020074/DA/NIDA NIH HHS; DA021456/DA/NIDA NIH HHS; DA05534/DA/NIDA NIH HHS; F32 DA021456/DA/NIDA NIH HHS; F32 DA021456-01/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen
Comments/Corrections

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