Document Detail

Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer.
MedLine Citation:
PMID:  11435067     Owner:  NLM     Status:  MEDLINE    
Normal tumour-adjacent breast tissue samples from 12 breast cancer patients forming six monozygotic twin pairs were analysed for loss of heterozygosity (LOH) on chromosomes 1, 13 and 17. 7 patients showed LOH at one or more markers. Each of them had a different LOH pattern. Only one twin pair showed LOH at the same locus, but the twins had lost a different allele. Multiple (n=1-13), histologically normal samples were collected from 6 bladder cancer patients and analysed for LOH on chromosomes 3 and 9. On chromosome 9, all 6 patients analysed showed LOH in at least one sample and one marker. Four of them also showed LOH on chromosome 3. Samples surrounding different tumours of a given patient resembled each other. More heterogeneity was seen between the patients, even though they shared some similarities in LOH clustering. The results demonstrate that tumour-adjacent normal tissues already harbour genetic changes typical for tumours. These alterations can reveal the earliest changes leading to tumorigenesis.
A Försti; J Louhelainen; M Söderberg; H Wijkström; K Hemminki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  37     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  1372-80     Citation Subset:  IM    
Department of Biosciences at Novum, Karolinska Institute, S-14157, Huddinge, Sweden.
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MeSH Terms
Breast Neoplasms / genetics*
Chromosomes, Human, Pair 1 / genetics
Chromosomes, Human, Pair 13 / genetics
Chromosomes, Human, Pair 17 / genetics
Chromosomes, Human, Pair 3 / genetics
Chromosomes, Human, Pair 9 / genetics
Loss of Heterozygosity*
Microsatellite Repeats
Twins, Monozygotic
Urinary Bladder Neoplasms / genetics*

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