Document Detail

Loss of heterozygosity in non-tumoral tissue in two children with Beckwith-Wiedemann syndrome.
MedLine Citation:
PMID:  1688177     Owner:  NLM     Status:  MEDLINE    
The Insulin-like growth factor II (IGF-II) gene has been analysed by Southern blotting in healthy and tumor tissue in two children with Beckwith-Wiedemann syndrome, using the enzymes, AvaII and SacI. Loss of heterozygosity was determined not only in the DNA of a nephroblastoma, but also in the healthy kidney, leukocytes and fragments of tongue removed for obstructive macroglossia. Allele loss therefore seems to be sufficient to provoke tumorigenesis in some tissues, but not in others.
H Schneid; M P Vazquez; D Seurin; Y le Bouc
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Growth regulation     Volume:  1     ISSN:  0956-523X     ISO Abbreviation:  Growth Regul.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1993-01-07     Completed Date:  1993-01-07     Revised Date:  2008-08-23    
Medline Journal Info:
Nlm Unique ID:  9106990     Medline TA:  Growth Regul     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  168-70     Citation Subset:  IM    
Institut National de la Santé et de la Recherche Médicale U.142, Hôpital Saint Antoine, Paris, France.
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MeSH Terms
Beckwith-Wiedemann Syndrome / genetics*
Blotting, Southern
DNA, Neoplasm / analysis
Deoxyribonucleases, Type II Site-Specific
Insulin-Like Growth Factor II / genetics*
Kidney Neoplasms / genetics
Leukocytes / chemistry
Polymorphism, Restriction Fragment Length
Tongue / chemistry
Wilms Tumor / genetics
Reg. No./Substance:
0/DNA, Neoplasm; 67763-97-7/Insulin-Like Growth Factor II; EC 3.1.21.-/endodeoxyribonuclease SacI; EC, Type II Site-Specific; EC type II deoxyribonucleases

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