| Loss of heterozygosity in non-tumoral tissue in two children with Beckwith-Wiedemann syndrome. | |
MedLine Citation:
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PMID: 1688177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Insulin-like growth factor II (IGF-II) gene has been analysed by Southern blotting in healthy and tumor tissue in two children with Beckwith-Wiedemann syndrome, using the enzymes, AvaII and SacI. Loss of heterozygosity was determined not only in the DNA of a nephroblastoma, but also in the healthy kidney, leukocytes and fragments of tongue removed for obstructive macroglossia. Allele loss therefore seems to be sufficient to provoke tumorigenesis in some tissues, but not in others. |
Authors:
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H Schneid; M P Vazquez; D Seurin; Y le Bouc |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Growth regulation Volume: 1 ISSN: 0956-523X ISO Abbreviation: Growth Regul. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1993-01-07 Completed Date: 1993-01-07 Revised Date: 2008-08-23 |
Medline Journal Info:
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Nlm Unique ID: 9106990 Medline TA: Growth Regul Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 168-70 Citation Subset: IM |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale U.142, Hôpital Saint Antoine, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Beckwith-Wiedemann Syndrome
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genetics* Blotting, Southern DNA, Neoplasm / analysis Deoxyribonucleases, Type II Site-Specific Female Heterozygote* Humans Infant Insulin-Like Growth Factor II / genetics* Kidney Neoplasms / genetics Leukocytes / chemistry Male Polymorphism, Restriction Fragment Length Tongue / chemistry Wilms Tumor / genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 67763-97-7/Insulin-Like Growth Factor II; EC 3.1.21.-/endodeoxyribonuclease SacI; EC 3.1.21.4/Deoxyribonucleases, Type II Site-Specific; EC 3.1.21.4/GGWCC-specific type II deoxyribonucleases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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