Document Detail

Loss of heterozygosity in adenomyosis on hMSH2, hMLH1, p16Ink4 and GALT loci.
MedLine Citation:
PMID:  11078826     Owner:  NLM     Status:  MEDLINE    
Adenomyosis is a gynecological condition in which tissue histologically similar to that in endometrium is found within the myometrium in the uterus. Although, lesions of both adenomyosis and endometriosis are identical to their sources with respect to structure and function, they are generally regarded as separate and distinct nosologic processes. In this study, we used 17 microsatellite markers, in four tetraplex and one single PCR assay, to determine the incidence of loss of heterozygosity (LOH) in 31 cases of adenomyosis. The markers used are located close to tumor suppressor genes, DNA repair genes, and genes which are thought to be involved in endometriosis. Moreover, the markers were involved in regions frequently lost in ovarian cancer, on chromosomal arms 1p, 1q, 2p, 2q, 3p, 9p, 9q, 17p and 17q. Nine samples (29.0%) showed LOH in at least one locus. Loci 2p22.3-p16.1, 3p24.2-p22 and 9p21 exhibited imbalance (19.4%, 9.7% and 6.5% respectively). This is the first report, that LOH occurs in adenomyosis. The regional chromosomal losses were detectable early during the development of this condition. In addition, hMSH2, hMLH1, p16Ink4 and GALT genes were associated for the first time with adenomyosis and its pathogenesis.
A G Goumenou; D A Arvanitis; I M Matalliotakis; E E Koumantakis; D A Spandidos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  6     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-07     Completed Date:  2001-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  667-71     Citation Subset:  IM    
Department of Virology, Medical School, University of Crete, Heraklion, Crete, Greece.
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MeSH Terms
Adaptor Proteins, Signal Transducing
Analysis of Variance
Carrier Proteins
Cyclin-Dependent Kinase Inhibitor p16 / genetics
DNA / genetics
DNA-Binding Proteins*
Endometriosis / genetics*,  pathology
Loss of Heterozygosity*
Microsatellite Repeats
Middle Aged
MutS Homolog 2 Protein
Neoplasm Proteins / genetics
Nuclear Proteins
Polymerase Chain Reaction
Proteins / genetics*
Proto-Oncogene Proteins / genetics
UTP-Hexose-1-Phosphate Uridylyltransferase / genetics
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Carrier Proteins; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/DNA-Binding Proteins; 0/MLH1 protein, human; 0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proteins; 0/Proto-Oncogene Proteins; 9007-49-2/DNA; EC Uridylyltransferase; EC protein, human; EC Homolog 2 Protein

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