Document Detail

Loss of heterozygosity of the BRCA1 and FHIT genes in patients with sporadic breast cancer from Southern Brazil.
MedLine Citation:
PMID:  15047740     Owner:  NLM     Status:  MEDLINE    
AIM: The evaluation of allelic losses at the FHIT and the BRCA1 genes and at three other loci at the 17q region in a series of 34 sporadic breast cancer cases from Southern Brazil.
METHODS: The samples were evaluated for loss of heterozygosity (LOH) at the FHIT and the BRCA1 genes and at three other microsatellite markers at 17q, and the findings were correlated with clinicopathological parameters.
RESULTS: The BRCA1 intragenic marker, D17S855, had the highest frequency of LOH, detected in 10 of 24 informative cases, followed by the D17S579 (six of 23 informative cases), D17S806 (five of 21 informative cases), and D17S785 markers (five of 21 informative cases). LOH at the FHIT intragenic marker, D3S1300, was found in six of 25 informative cases. In four of the six cases with LOH of the FHIT gene, there was concomitant loss of the BRCA1 intragenic marker.
CONCLUSIONS: The frequency of allelic losses in the FHIT and BRCA1 loci in the Southern Brazilian population is similar to that described in the general population. No correlations were found when the total LOH frequency was compared with tumour size, grade, or presence of axillary lymph node metastasis. Further studies using larger sporadic breast cancer samples and additional markers would be useful to confirm these findings, in addition to establishing more specific associations with clinicopathological parameters in this specific population.
S C L Santos; L R Cavalli; I J Cavalli; R S Lima; B R Haddad; E M S F Ribeiro
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  57     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-05-13     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  AIM; IM    
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MeSH Terms
Acid Anhydride Hydrolases*
Breast Neoplasms / genetics*,  pathology
Carcinoma, Ductal, Breast / genetics*,  pathology
Chi-Square Distribution
Gene Frequency
Genes, BRCA1*
Genetic Markers
Loss of Heterozygosity*
Lymphatic Metastasis
Middle Aged
Neoplasm Proteins / genetics*
Polymerase Chain Reaction / methods
Reg. No./Substance:
0/Genetic Markers; 0/Neoplasm Proteins; 0/fragile histidine triad protein; EC 3.6.-/Acid Anhydride Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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