| Loss of the extra chromosome 21 in a patient with Down syndrome and myelodysplasia. | |
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MedLine Citation:
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PMID: 18068540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monosomy 21 is a rare acquired karyotypic abnormality associated with myeloid disorders. Occurrence of loss of one chromosome 21 in the background of trisomy 21 in Down syndrome, resulting in the pseudo-normalization of trisomy 21, is a novel finding. The case is described of a patient with Down syndrome who acquired such a genetic abnormality as a result of myelodysplastic syndrome. |
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Authors:
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Daryl Tan; Lai Ching Lau; Li Min Teng; Swati Sane; Tse Hui Lim; Sim Leng Tien |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 180 ISSN: 0165-4608 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-10 Completed Date: 2008-02-26 Revised Date: 2008-03-06 |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 79-82 Citation Subset: IM |
Affiliation:
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Department of Hematology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore. daryl.tan@sgh.com.com.sg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosomes, Human, Pair 21* Down Syndrome / complications*, genetics* Female Humans Karyotyping Middle Aged Mosaicism Myelodysplastic Syndromes / complications*, genetics* Trisomy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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