Document Detail


Loss of expression of E-cadherin and beta-catenin is associated with progression of pulmonary adenocarcinoma.
MedLine Citation:
PMID:  15660698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to determine the association of loss of membranous expression of epithelial (E)-cadherin and beta-catenin with the progression of pulmonary adenocarcinoma. The expression of E-cadherin and beta-catenin was examined in 154 cases of pulmonary adenocarcinoma, including 49 cases of atypical adenomatous hyperplasia (AAH), 40 cases of bronchioloalveolar carcinoma (BAC), 42 cases of BAC-dominant type of adenocarcinoma with mixed subtypes (early MX) and 23 cases of BAC-recessive type of adenocarcinoma with mixed subtypes (overt MX), by immunohistochemistry. E-cadherin expression was positive in all cases of AAH, in 37 cases (92.5%) of BAC and in 34 cases (81.0%) of early MX, while it was positive in three cases (13.0%) of overt MX. beta-Catenin expression was positive in 47 cases (95.9%) of AAH, in 28 cases (70%) of BAC, in 32 cases (76.2%) of early MX and in 11 cases (47.8%) of overt MX. The rates of expression of E-cadherin and beta-catenin among cases of AAH, BAC, early MX and overt MX were significantly reduced. Loss of expression of E-cadherin and beta-catenin may play an important role in the progression of pulmonary adenocarcinoma, and these events occur before structural destruction of the alveolar wall by invasion of carcinoma cell.
Authors:
Hirokazu Awaya; Yukio Takeshima; Vishwa Jeet Amatya; Hajime Ishida; Masahiro Yamasaki; Nobuoki Kohno; Kouki Inai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  55     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-21     Completed Date:  2005-06-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, Postgraduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima 734-8551, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism*,  pathology*
Adult
Aged
Aged, 80 and over
Cadherins / biosynthesis*
Cytoskeletal Proteins / biosynthesis*
Female
Humans
Immunohistochemistry
Lung Neoplasms / metabolism*,  pathology*
Lymphatic Metastasis / pathology
Male
Middle Aged
Trans-Activators / biosynthesis*
Tumor Markers, Biological / analysis
beta Catenin
Chemical
Reg. No./Substance:
0/CTNNB1 protein, human; 0/Cadherins; 0/Cytoskeletal Proteins; 0/Trans-Activators; 0/Tumor Markers, Biological; 0/beta Catenin

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