Document Detail


Loss of contact sensitization evaluated by laser Doppler blood flowmetry and transepidermal water loss measurement.
MedLine Citation:
PMID:  8730158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Allergic contact dermatitis, which is mediated by activated T cells through a Type IV reaction, is usually believed to persist throughout life. There have been several reports of spontaneous loss of sensitization, e.g., loss of previous patch test reaction or loss of allergic contact dermatitis withal continuous exposure to the allergens. However, these have been well quantified. The aim of this study was to confirm the development of desensitization or hyposensitization with the aid of objective measurements. A total of 18 patients with alopecia areata, who received 4 months diphenylcyclopropenone (DPCP) contact immunotherapy, were patch tested and the responses were measured by laser Doppler blood flowmetry (LDF) and transepidermal water loss (TEWL). Patch tests were performed 2X, before and after 4 months of immunotherapy. To determine whether local desensitization developed, we compared change of DPCP concentrations producing mild contact dermatitis on the scalp. Our results showed that systemic and local hyposensitization occurred in human subjects by weekly applications of low concentrations of DPCP for 4 months. LDF seems to be more correlated with visual scores than TEWL measurement.
Authors:
K I Seo; H C Eun
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  34     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-17     Completed Date:  1996-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Seoul National University, College of Medicine, Korea.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adolescent
Adult
Alopecia Areata / complications,  drug therapy,  immunology*
Blood Flow Velocity
Child
Child, Preschool
Cyclopropanes / adverse effects,  therapeutic use
Dermatitis, Allergic Contact / etiology,  immunology*
Desensitization, Immunologic*
Female
Humans
Immunotherapy
Laser-Doppler Flowmetry*
Male
Middle Aged
Patch Tests
Skin / blood supply
Skin Physiological Phenomena*
Water Loss, Insensible / physiology*
Chemical
Reg. No./Substance:
0/Cyclopropanes; 886-38-4/diphenylcyclopropenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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