Document Detail

Loss of circadian blood pressure variability in complete tetraplegia.
MedLine Citation:
PMID:  8817405     Owner:  NLM     Status:  MEDLINE    
Blood pressure (BP) and heart rate (HR) were monitored over 24 h utilising an ambulatory blood pressure monitoring (ABPM) system in 33 subjects with spinal cord injury: 11 patients with complete tetraplegia, 13 patients with incomplete tetraplegia and nine patients with complete paraplegia. Measurements were analysed for overall levels of BP and HR, presence of a physiological day/night cycle and events of autonomic dysreflexia. Paraplegic patients exhibited normal BP and HR levels with a physiological circadian rhythm. In complete tetraplegic patients the circadian rhythm was abolished for BP but preserved for HR, while in patients with incomplete tetraplegia circadian rhythm was preserved for both BP and HR. Complete tetraplegic patients with autonomic dysreflexia revealed a typical pattern in ABPM with multiple hypertensive episodes and concomitant bradycardia. Under adequate treatment these episodes could be reduced or abolished, while the disturbed circadian BP rhythm persisted. These observations shed further light on mechanisms of central BP and HR control. In tetraplegic patients ABPM is an efficient method to assess treatment for autonomic dysreflexia.
B Nitsche; H Perschak; A Curt; V Dietz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  10     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  IM    
Swiss Paraplegic Centre, University Hospital Balgrist, Zürich, Switzerland.
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MeSH Terms
Autonomic Nervous System / physiopathology
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm*
Heart Rate
Middle Aged
Neurologic Examination
Paraplegia / physiopathology
Quadriplegia / physiopathology*
Reflex, Abnormal
Spinal Cord Injuries / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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