Document Detail

Loss of cardiac myofibrils: mechanism of contractile deficits induced by taurine deficiency.
MedLine Citation:
PMID:  8476107     Owner:  NLM     Status:  MEDLINE    
It is well established that taurine deficiency is associated with myocardial contractile dysfunction; however, the mechanism is unknown. As a follow-up to finding reduced force generation in taurine-depleted rat cardiac trabeculae, using either calcium or strontium activation, this study examined alterations in ventricular fine structure and contractile proteins in animals made taurine deficient by in vivo treatment with a taurine transport antagonist, guanidinoethane sulfonate. Observations of ventricular ultrastructure showed disordered contractile filaments and clear losses of myofibrillar bundles in association with taurine deficiency. Biochemical analyses of ventricular contractile proteins using polyacrylamide gel electrophoresis confirmed losses of the major sarcomeric proteins, myosin and actin. These findings provide a possible mechanism for the contractile deficits and cardiomyopathy described in taurine-deficient animals.
N Lake
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-17     Completed Date:  1993-05-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1323-6     Citation Subset:  IM    
Department of Physiology, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Actins / analysis,  ultrastructure
Calcium / pharmacology
Contractile Proteins / analysis,  ultrastructure
Electrophoresis, Polyacrylamide Gel
Heart / physiology
Microscopy, Electron
Myocardial Contraction / physiology*
Myocardium / chemistry,  pathology,  ultrastructure*
Myofibrils / chemistry,  physiology*,  ultrastructure
Myosins / analysis,  ultrastructure
Sarcomeres / chemistry,  pathology,  ultrastructure
Strontium / pharmacology
Taurine / analogs & derivatives,  deficiency*,  pharmacology,  physiology*
Reg. No./Substance:
0/Actins; 0/Contractile Proteins; 107-35-7/Taurine; 543-18-0/taurocyamine; 7440-24-6/Strontium; 7440-70-2/Calcium; EC

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