| Loss of cardiac myofibrils: mechanism of contractile deficits induced by taurine deficiency. | |
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MedLine Citation:
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PMID: 8476107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well established that taurine deficiency is associated with myocardial contractile dysfunction; however, the mechanism is unknown. As a follow-up to finding reduced force generation in taurine-depleted rat cardiac trabeculae, using either calcium or strontium activation, this study examined alterations in ventricular fine structure and contractile proteins in animals made taurine deficient by in vivo treatment with a taurine transport antagonist, guanidinoethane sulfonate. Observations of ventricular ultrastructure showed disordered contractile filaments and clear losses of myofibrillar bundles in association with taurine deficiency. Biochemical analyses of ventricular contractile proteins using polyacrylamide gel electrophoresis confirmed losses of the major sarcomeric proteins, myosin and actin. These findings provide a possible mechanism for the contractile deficits and cardiomyopathy described in taurine-deficient animals. |
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Authors:
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N Lake |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 264 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-17 Completed Date: 1993-05-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1323-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, McGill University, Montreal, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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analysis,
ultrastructure Animals Calcium / pharmacology Contractile Proteins / analysis, ultrastructure Electrophoresis, Polyacrylamide Gel Heart / physiology Microscopy, Electron Myocardial Contraction / physiology* Myocardium / chemistry, pathology, ultrastructure* Myofibrils / chemistry, physiology*, ultrastructure Myosins / analysis, ultrastructure Rats Sarcomeres / chemistry, pathology, ultrastructure Strontium / pharmacology Taurine / analogs & derivatives, deficiency*, pharmacology, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Contractile Proteins; 107-35-7/Taurine; 543-18-0/taurocyamine; 7440-24-6/Strontium; 7440-70-2/Calcium; EC 3.6.4.1/Myosins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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