Document Detail


Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice.
MedLine Citation:
PMID:  9501238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult. Surprisingly, gene-targeted mice lacking a functional GRP-R gene develop and reproduce normally and show no gross phenotypic abnormalities. However, peripheral administration of bombesin at dosages up to 32 nmol/kg to such mice had no effect on the suppression of glucose intake, whereas normal mice showed a dose-dependent suppression of glucose intake. These data suggest that selective agonists for the GRP-R may be useful in inducing satiety.
Authors:
L L Hampton; E E Ladenheim; M Akeson; J M Way; H C Weber; V E Sutliff; R T Jensen; L J Wine; H Arnheiter; J F Battey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  95     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-10     Completed Date:  1998-04-10     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3188-92     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.
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MeSH Terms
Descriptor/Qualifier:
Amylases / secretion
Animals
Bombesin / pharmacology*
Carbachol / pharmacology
Dose-Response Relationship, Drug
Eating / drug effects*
Mice
Mice, Mutant Strains
Pancreas / drug effects
Receptors, Bombesin / agonists,  deficiency*,  genetics
Satiation / physiology*
Sincalide / pharmacology
Chemical
Reg. No./Substance:
0/Receptors, Bombesin; 25126-32-3/Sincalide; 31362-50-2/Bombesin; 51-83-2/Carbachol; EC 3.2.1.-/Amylases
Comments/Corrections

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