| Loss of androgenic induction of alpha 2u-globulin gene family in the liver of NIH black rats. | |
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MedLine Citation:
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PMID: 2474439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Unlike all known strains of rat, the androgen-inducible alpha 2u-globulin gene family is totally silent in the liver of NIH black (NB) rats. No endocrinological or reproductive abnormalities are apparent, and the mRNA for the androgen-repressible hepatic protein SMP-2 is normally regulated in these animals. Furthermore, immunoblot analysis shows a normal level of the male-specific cytoplasmic androgen-binding protein. Cross-breeding of the NB male and Sprague-Dawley female shows that the hybrid male in the F-1 generation regains the androgen-dependent expression of alpha 2u-globulin in the liver. These results along with the observation of high constitutive level of alpha 2u-globulin mRNA in the preputial gland of NB rats indicate a tissue- and gene-specific regulatory defect which prevents androgenic induction of alpha 2u-globulin in the liver. |
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Authors:
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B Chatterjee; W F Demyan; C S Song; B D Garg; A K Roy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrinology Volume: 125 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1989-09-20 Completed Date: 1989-09-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1385-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alpha-Globulins
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genetics* Androgen-Binding Protein / genetics Animals Blotting, Northern Cytosol / metabolism Dihydrotestosterone / pharmacology Female Gene Expression Regulation Genes* / drug effects Liver / drug effects, metabolism* Male Multigene Family* / drug effects Ovariectomy* Protein Biosynthesis RNA / genetics*, isolation & purification Rats Rats, Inbred Strains Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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AG-03527/AG/NIA NIH HHS; DK-14744/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alpha-Globulins; 0/Androgen-Binding Protein; 521-18-6/Dihydrotestosterone; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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