Document Detail

Loss of anatomical landmarks with eutectic mixture of local anesthetic cream for neonatal male circumcision.
MedLine Citation:
PMID:  23102766     Owner:  NLM     Status:  MEDLINE    
We report two cases of newborns who developed marked local edema after application of a eutectic mixture of local anesthetic (EMLA) topical anesthetic cream for neonatal male circumcision (NMC). Although local edema and erythema are known potential side effects of EMLA cream, a common anesthetic used for NMC, the loss of landmarks precluding safe NMC has not previously been reported, and is described here. Although we cannot recommend an alternate local anesthetic for neonates with this reaction to EMLA, based on a review of the published data we think that serious systemic adverse events related to EMLA are extremely rare.
Rebeca M Plank; David W Kubiak; Rasak Bamidele Abdullahi; Nnamdi Ndubuka; Maggie M Nkgau; Fredrick Dapaah-Siakwan; Kathleen M Powis; Shahin Lockman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-24
Journal Detail:
Title:  Journal of pediatric urology     Volume:  9     ISSN:  1873-4898     ISO Abbreviation:  J Pediatr Urol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-20     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101233150     Medline TA:  J Pediatr Urol     Country:  England    
Other Details:
Languages:  eng     Pagination:  e86-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Administration, Topical
Anatomic Landmarks / pathology*
Circumcision, Male / methods*
Edema / chemically induced*,  pathology
Foreskin / drug effects*,  pathology
Infant, Newborn
Lidocaine / administration & dosage,  adverse effects*
Prilocaine / administration & dosage,  adverse effects*
Skin Cream / administration & dosage,  adverse effects
Grant Support
Reg. No./Substance:
0/EMLA; 046O35D44R/Prilocaine; 98PI200987/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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