Document Detail


Loss of acute satiety response to cholecystokinin in pregnant rats.
MedLine Citation:
PMID:  21771116     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
During pregnancy, food intake and fat mass are increased to meet the energy demands of the growing conceptus and to prepare for the subsequent demands of lactation. A state of leptin resistance develops during pregnancy in the rat, which can facilitate the increase in food intake despite pregnancy-induced increases in leptin concentrations. Cholecystokinin (CCK) is a satiety factor that is released from the gut during feeding and acts to terminate short-term food intake. Circulating leptin concentrations can modulate the anorexic response to CCK; low leptin concentrations decrease the potency of CCK to reduce food intake. As rats are leptin resistant by day 14 of pregnancy, it was hypothesized that the feeding response to CCK would be attenuated at that time. Nonpregnant and day 14 pregnant rats received an intraperitoneal injection of CCK-8 (3μg/kg BW) or vehicle directly before the start of the dark phase. Food intake was measured 30 minutes after lights out. Approximately 90 minutes after receiving either CCK-8 or vehicle, rats were transcardially perfused with 4% paraformaldehyde. Food intake was significantly decreased in CCK-treated nonpregnant rats, but similar treatment did not reduce food intake in day 14 pregnant rats. CCK treatment lead to significant increased in c-Fos expression in the nucleus of the solitary tract (NTS) in both nonpregnant and pregnant rats compared to vehicle treatment, but the number of CCK-induced c-Fos positive cells was significantly less in pregnant rat compared to nonpregnant rats. While CCK treatment increased the number of c-Fos positive cells in the hypothalamic paraventricular nucleus and supraoptic nucleus in nonpregnant rats, no significant increase was observed in these areas during pregnancy. These results indicate that pregnant rats are no longer responsive to the actions of CCK on short-term food intake and that CCK action in the NTS is reduced during pregnancy.
Authors:
Sharon R Ladyman; Tony J Sapsford; David R Grattan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-19
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  -     ISSN:  1365-2826     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal of Neuroendocrinology © 2011 Blackwell Publishing.
Affiliation:
Centre for Neuroendocrinology, and Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand.
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