Document Detail

Loss of the Y chromosome in a cultured human salivary-gland adenocarcinoma.
MedLine Citation:
PMID:  6418867     Owner:  NLM     Status:  MEDLINE    
Using in vitro methods, the G-banding pattern in a highly differentiated adenocarcinoma of the parotid gland is described. Results from two consecutive preparations of the carcinoma indicated that it had originated with a normal diploid stemline and, subsequently, during progression had developed an aneuploid stemline deviating from the normal only by loss of the Y chromosome. From this hypodiploid stemline some clones and variant cells had been generated, all of them characterized by numerical deviations, particularly various trisomies. Important cytogenetic similarities were found between the present adenocarcinoma and other types of salivary gland neoplasms, in particular pleomorphic adenomas.
G Stenman; J Mark
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of oral pathology     Volume:  12     ISSN:  0300-9777     ISO Abbreviation:  J. Oral Pathol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0342050     Medline TA:  J Oral Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  458-64     Citation Subset:  D; IM    
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MeSH Terms
Adenocarcinoma / genetics*
Chromosome Banding
Parotid Gland / ultrastructure
Parotid Neoplasms / genetics*
Sex Chromosome Aberrations / genetics*
Y Chromosome / ultrastructure*

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