Document Detail

Loss of the Y chromosome in bone marrow cells: results on 1907 consecutive cases of leukaemia and preleukaemia.
MedLine Citation:
PMID:  10197258     Owner:  NLM     Status:  MEDLINE    
Loss of the Y chromosome with a resulting 45, X0 karyotype is observed in normal bone marrow cells of elderly males but also in haematological malignancies. Whether Y loss in neoplastic cells is related to the process seen in normal ageing or is part of the carcinogenic process is unknown. The present study concerns the cytogenetic data from 1907 consecutive leukaemic or preleukaemic male patients with special regard to the presence or absence of the Y chromosome. Sixty-five patients (3.4%) had a 45, X-Y clone in their bone marrow (BM) cells. Loss of Y was rare below the age of 50 but increased in older patients, reaching 25% of the men over 80. Sixteen patients (0.08%) had more than 90% X0 cells in their BM. A correlation between Y loss and leukaemia could be established in seven cases, three of which were acute myeloid leukaemia M2 subtype where -Y is known to be a secondary event. In three other cases, -Y was part of a complex karyotype. Only one patient exhibited a 45, X0 karyotype, with no other rearrangement, that could be positively correlated with the neoplastic process.
C Herens; E Brasseur; M Jamar; L Vierset; I Schoenen; L Koulischer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  21     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
Centre for Human Genetics, Liège University, CHU, Tour de Pathologie, Belgium.
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MeSH Terms
Aged, 80 and over
Bone Marrow Cells / ultrastructure*
Chromosome Deletion
Leukemia / genetics*,  pathology
Metaphase / genetics
Middle Aged
Preleukemia / genetics*,  pathology
Y Chromosome* / genetics

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