Document Detail

Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma.
MedLine Citation:
PMID:  21421870     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study relationships between glaucoma-sensitive components identified with frequency-domain analysis of global-flash multifocal electroretinogram (mfERG), regional retinal nerve fiber layer thickness (RNFLT), and local visual field sensitivity (VS).
METHODS: Eleven macaque monkeys, including four controls and seven with unilateral laser-induced trabecular meshwork scarification and ocular hypertension, were observed with optical coherence tomography (OCT), full-field light-adapted flash ERG, 103-hexagon global-flash mfERG (MFOFO), and static perimetry. The effects of experimental glaucoma on mfERG were assessed in the frequency domain. Relations between root mean square (RMS) amplitude of a glaucoma-sensitive frequency range and peripapillary RNFLT (standard 12° OCT circular scan), and between RMS amplitude and VS were studied.
RESULTS: Experimental glaucoma led to a dramatic and consistent power loss in the low-frequency (<25 Hz) band of mfERG. The RMS of this low-frequency component (LFC) correlated significantly with the regional RNFLT. The r(2) of linear fits was 0.39 (P < 0.001) for cross-sectional group data and 0.60 after correction for intersubject variability. The r(2) of linear fits for longitudinal data from individual animals was as high as 0.78 (P < 0.001). Local LFC RMS amplitude also correlated significantly with interpolated VS for hexagons. The r(2) for exponential fits of hexagon LFC RMS amplitudes (inner three rings) versus VS (dB) was 0.29 to 0.52 (P < 0.001) for the group and up to 0.95 in individuals.
CONCLUSIONS: The significant correlations between regional measures of global-flash mfERG, RNFLT, and VS suggest that LFC RMS amplitude provides a useful index for objective quantification of local RGC function and monitoring of early changes in glaucoma.
Xunda Luo; Nimesh B Patel; Ronald S Harwerth; Laura J Frishman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-01
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-08-19     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3792-804     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal*
Glaucoma / diagnosis,  physiopathology*
Laser Therapy
Macaca mulatta
Nerve Fibers / physiology*
Ocular Hypertension / diagnosis,  physiopathology
Optic Nerve Diseases / diagnosis,  physiopathology*
Photic Stimulation*
Retinal Ganglion Cells / physiology*
Tomography, Optical Coherence
Trabecular Meshwork / surgery
Visual Field Tests
Visual Fields / physiology
Grant Support
P30 EY007551/EY/NEI NIH HHS; P30 EY007551-24/EY/NEI NIH HHS; P30 EY007551-25/EY/NEI NIH HHS; P30-EY07751/EY/NEI NIH HHS; R01 EY001139/EY/NEI NIH HHS; R01 EY006671/EY/NEI NIH HHS; R01 EY006671-16/EY/NEI NIH HHS; R01-EY01139/EY/NEI NIH HHS; R01-EY06671/EY/NEI NIH HHS

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