Document Detail


Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.
MedLine Citation:
PMID:  25438849     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Echogenic liposomes (ELIP) are being developed for the early detection and treatment of atherosclerotic lesions. An 80% loss of echogenicity of ELIP has been found to be concomitant with the onset of stable and inertial cavitation. The ultrasound pressure amplitude at which this occurs is weakly dependent on pulse duration. It has been reported that the rapid fragmentation threshold of ELIP (based on changes in echogenicity) is dependent on the insonation pulse repetition frequency (PRF). The study described here evaluates the relationship between loss of echogenicity and cavitation emissions from ELIP insonified by duplex Doppler pulses at four PRFs (1.25, 2.5, 5 and 8.33 kHz). Loss of echogenicity was evaluated on B-mode images of ELIP. Cavitation emissions from ELIP were recorded passively on a focused single-element transducer and a linear array. Emissions recorded by the linear array were beamformed, and the spatial widths of stable and inertial cavitation emissions were compared with the calibrated azimuthal beamwidth of the Doppler pulse exceeding the stable and inertial cavitation thresholds. The inertial cavitation thresholds had a very weak dependence on PRF, and stable cavitation thresholds were independent of PRF. The spatial widths of the cavitation emissions recorded by the passive cavitation imaging system agreed with the calibrated Doppler beamwidths. The results also indicate that 64%-79% loss of echogenicity can be used to classify the presence or absence of cavitation emissions with greater than 80% accuracy.
Authors:
Kirthi Radhakrishnan; Kevin J Haworth; Tao Peng; David D McPherson; Christy K Holland
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Publication Detail:
Type:  Journal Article     Date:  2014-11-15
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  41     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2015 Jan 
Date Detail:
Created Date:  2014-12-06     Completed Date:  -     Revised Date:  2014-12-08    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  208-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL059586/HL/NHLBI NIH HHS; R01 HL074002/HL/NHLBI NIH HHS

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