| Loss of Compliance in Small Arteries, but Not in Conduit Arteries, After 6 Weeks Exposure to High Fat Diet. | |
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MedLine Citation:
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PMID: 22467359 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Arterial stiffness is a key marker in metabolic diseases and can be evaluated by arterial compliance. Most compliance measurements are performed in large conduit arteries in advanced stage of metabolic diseases, which may not provide information on mechanisms associated with the initiation of the pathology. For this reason, we compared arterial compliance of two different size arteries: carotid and a smaller artery (thoracodorsal artery, TDA). The arterial compliance was compared between control and high fat-fed mice for 6 weeks. We show that the compliance of the TDAs was dramatically reduced in high fat-fed mice whereas the compliance of the carotids remained unchanged. An abundance of collagen deposition in the media/adventitia of the carotids and TDAs was observed in high fat-fed mice. These results demonstrate that the structural and mechanical properties of small arteries are rapidly altered even after only 6 weeks of high fat feeding. |
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Authors:
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Marie Billaud; Scott R Johnstone; Brant E Isakson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-31 |
Journal Detail:
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Title: Journal of cardiovascular translational research Volume: - ISSN: 1937-5395 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-4-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101468585 Medline TA: J Cardiovasc Transl Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, P.O. Box 801394, Charlottesville, VA, 22908, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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