Document Detail

Losartan vs. amlodipine treatment in elderly oncologic hypertensive patients: A randomized clinical trial.
MedLine Citation:
PMID:  20569998     Owner:  NLM     Status:  In-Data-Review    
Elderly neoplastic patients frequently may show hypertension and hyperuricemia, before and after chemotherapeutic treatments. The purpose of this study was to evaluate the efficacy of losartan which is an antihypertensive drug with uricosuric properties vs. amlodipine in hypertensive neoplastic elderly patients. This was an open-labeled, randomized, comparative trial. The study was performed as a 30-day study. Seventy patients with cancer were randomly assigned to receive losartan or amlodipine. Blood pressure (BP), blood urea nitrogen (BUN) levels, creatinine, serum and urinary uric acid, creatinine and uric acid clearance were determined before and after chemotherapy. One day after chemotherapy in losartan group vs. amlodipine group we observed a significant difference in urinary uric acid (p<0.001) of 18mg/24h vs. 40mg/24h. Thirty days after chemotherapy we observed a significant difference in azotemia of 0.0mg/dl vs. 3.8mg/dl (p<0.001), serum uric acid of 0.05mg/dl vs. 0.49mg/dl (p<0.001), urinary uric acid (p<0.001) of 23mg/24h vs. 0.0mg/24h, GFR of 2ml/min/1.73m(2) vs. -8ml/min/1.73m(2) (p<0.05) and systolic BP (SBP) of 3.6mmHg vs. 0.8mmHg (p<0.05). The findings of the present study support the effective role of losartan compared to amlodipine in treating hypertension and hyperuricemia in elderly patients under chemotherapeutic treatment.
Massimo Motta; Cristina Russo; Marco Vacante; Rocco Luca Emanuele Liardo; Francesca Reitano; Lisa Cammalleri; Mario Costanzo; Giuseppe Benfatto; Paola Frazzetto; Enrico Mondati; Michele Malaguarnera; Giovanni Pennisi
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Publication Detail:
Type:  Journal Article     Date:  2010-05-31
Journal Detail:
Title:  Archives of gerontology and geriatrics     Volume:  53     ISSN:  1872-6976     ISO Abbreviation:  Arch Gerontol Geriatr     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214379     Medline TA:  Arch Gerontol Geriatr     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  60-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Internal Medicine and Systemic Diseases, University of Catania, Cannizzaro Hospital, Via Messina 829, I-95125 Catania, Italy; Research Center "The Extreme Senescence", University of Catania, Cannizzaro Hospital, Via Messina 829, I-95125 Catania, Italy.
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