| Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 20145991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased production of free radicals and impairment of mitochondrial function are important factors in the pathogenesis of hypertension. This study examined the impact of hypertension on mitochondrial respiratory chain function, coenzyme Q(9) (CoQ(9)), coenzyme Q(10) (CoQ(10)), and alpha-tocopherol content in brain mitochondria, and the effect of blockade of angiotensin II type 1 receptors (AT1R) in the prehypertensive period on these parameters. In addition, blood pressure, heart and brain weight to body weight ratios, and the geometry of the basilar artery supplying the brain were evaluated. In the 9th week blood pressure and heart weight/body weight ratio were significantly increased and brain weight/body weight ratio was significantly decreased in spontaneously hypertensive rats (SHR) when compared to Wistar rats (WR). The cross-sectional area of the basilar artery was increased in SHR. Glutamate-supported respiration, the rate of ATP production, and concentrations of CoQ(9), CoQ(10), and alpha-tocopherol were decreased in SHR. The succinate-supported function and cytochrome oxidase activity were not changed. The treatment of SHR with losartan (20 mg/kg/day) from 4th to 9th week of age exerted preventive effect against hypertension, heart and arterial wall hypertrophy, and brain weight/body weight decline. After the therapy, the rate of ATP production and the concentration of CoQ increased in comparison to untreated SHR. The impairment of energy production and decreased level of lipid-soluble antioxidants in brain mitochondria as well as structural alterations in the basilar artery may contribute to increased vulnerability of brain tissue in hypertension. Long-term treatment with AT1R blockers may prevent brain dysfunction in hypertension. |
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Authors:
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Z Sumbalová; J Kucharská; F Kristek |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-10 |
Journal Detail:
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Title: Cellular and molecular neurobiology Volume: 30 ISSN: 1573-6830 ISO Abbreviation: Cell. Mol. Neurobiol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200709 Medline TA: Cell Mol Neurobiol Country: United States |
Other Details:
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Languages: eng Pagination: 751-8 Citation Subset: IM |
Affiliation:
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Pharmacobiochemical Laboratory of Third Department of Internal Medicine, Faculty of Medicine, Comenius University, Spitálska 24, 81372 Bratislava, Slovak Republic. zuzana.sumbalova@zoznam.sk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects* Angiotensin II Type 1 Receptor Blockers / pharmacology* Animals Antioxidants / metabolism Brain / drug effects, metabolism* Cell Respiration / drug effects Electron Transport / drug effects Electron Transport Complex IV / metabolism Glutamates / metabolism Losartan / pharmacology* Mitochondria / drug effects*, metabolism* Rats Rats, Inbred SHR Rats, Wistar Rotenone / pharmacology Succinic Acid / metabolism Ubiquinone / analogs & derivatives, metabolism* alpha-Tocopherol / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Antioxidants; 0/Glutamates; 110-15-6/Succinic Acid; 114798-26-4/Losartan; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10; 59-02-9/alpha-Tocopherol; 83-79-4/Rotenone; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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