Document Detail

Losartan associated anaphylaxis and angioneurotic oedema.
MedLine Citation:
PMID:  20726206     Owner:  NLM     Status:  MEDLINE    
A case of anaphylaxis and angioedema induced by angiotensin II receptor blocker (ARB), losartan is reported. A 37 years old hypertensive female presented to the Emergency Department with swelling over the face especially the lips, urticarial rash all over the body, and dyspnoea within an hour of losartan administration. She did not have any previous history of drug allergies. The patient was managed with epinephrine. Although angioneurotic oedema and anaphylaxis are well documented adverse effects of angiotensin converting enzyme (ACE) inhibitors, very few cases of these adverse reactions with ARBs have been reported in medical literature.
Syed Faraz Kazim; Muhammad Shahid
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  60     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  685-6     Citation Subset:  IM    
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.
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MeSH Terms
Anaphylaxis / chemically induced*,  drug therapy
Angioedema / chemically induced*,  drug therapy
Antihypertensive Agents / adverse effects*,  therapeutic use
Epinephrine / therapeutic use
Hypertension / drug therapy*
Losartan / adverse effects*,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 114798-26-4/Losartan; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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