Document Detail

Lorcainide -- an anti-arrhythmic agent for ventricular arrhythmias.
MedLine Citation:
PMID:  7404136     Owner:  NLM     Status:  MEDLINE    
The long-term anti-arrhythmic efficacy of lorcainide (R15 889) was studied in 20 ambulatory postmyocardial infarction patients. Lorcainide reduced the frequency of ventricular ectopic beats by more than 70% and 90% in 17 and 11 of the patients respectively. The anti-arrhythmic response improved with long-term administration of the drug. Fourteen patients complained of insomnia during the early stages of the study, but this side-effect waned later on. On electrocardiographic examination, the P-R interval, QTc interval and QRS duration were prolonged, and T-wave changes were noted while the patients were receiving lorcainide. Lorcainide seems to be a useful addition to the available anti-arrhythmic agents, and should form part of the armamentarium against ventricular ectopic activity.
D P Myburgh; A P Goldman; J M Schamroth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  57     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  236-9     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / complications,  drug therapy*
Middle Aged
Myocardial Infarction / complications
Piperidines / therapeutic use*
Ventricular Fibrillation / complications,  drug therapy*
Reg. No./Substance:
0/Benzeneacetamides; 0/Piperidines; 59729-31-6/lorcainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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