| Lorazepam given the night before surgery reduces preoperative anxiety in children undergoing reconstructive burn surgery. | |
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MedLine Citation:
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PMID: 10188113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A high level of preoperative anxiety frequently occurs in children undergoing reconstructive burn surgery. Reduction of this anxiety may have a number of physiological and psychological benefits. Various pharmaceutical and nonpharmaceutical regimens to reduce preoperative anxiety have been devised; however, most regimens are not initiated until the period immediately before surgery. Many of the children in our institution report high levels of anxiety beginning the night before surgery. Therefore we hypothesized that sedation the night before surgery would be beneficial. Oral lorazepam 0.025 mg/kg or placebo was given the night before surgery to 45 patients in a prospective, randomized, double-blind fashion; in addition, all patients received preoperative sedation per protocol on the day of surgery. Immediately before induction of anesthesia, all patients (mean age 12.5 +/- 0.9 years, range 6 to 18 years) performed an anxiety self-rating with the use of a validated visual analog scale (VAS). Patient anxiety and quality of anesthesia induction was also rated by one of the investigators. Postoperatively, patients rated their recall of anxiety with the use of the VAS. When queried preoperatively, patients who received lorazepam the night before surgery self-reported significantly less anxiety than those receiving placebo. Investigator observations did not detect this difference; this reinforces the assertion that patient self-rating of anxiety may be the best tool for rating anxiety. |
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Authors:
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J E McCall; C G Fischer; G Warden; R Kopcha; S Lloyd; J Young; B Schomaker |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 20 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1999 Mar-Apr |
Date Detail:
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Created Date: 1999-06-04 Completed Date: 1999-06-04 Revised Date: 2006-08-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 151-4 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Shriners Hospital for Children-Cincinnati, Ohio 45229, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Anti-Anxiety Agents / therapeutic use* Anxiety / prevention & control* Burns / surgery* Chi-Square Distribution Child Double-Blind Method Female Humans Lorazepam / therapeutic use* Male Premedication* Preoperative Care Prospective Studies Reconstructive Surgical Procedures / methods, psychology Reference Values Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 846-49-1/Lorazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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