Document Detail


Loperamide but not morphine has anti-secretory effects in human colon, in vitro.
MedLine Citation:
PMID:  1802746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Isolated preparations of human colonic mucosa were set up in Ussing chambers. Noradrenaline reduced basal short-circuit current, morphine did not nor did loperamide except at the highest concentration tested. Electrically evoked increases in short-circuit current were unaffected by morphine but reduced by loperamide, by a naloxone-insensitive mechanism. Unidirectional fluxes of 22sodium and 36chloride were unaffected by morphine. It is concluded that loperamide but not morphine has an anti-secretory effect on human colonic mucosa.
Authors:
D E Burleigh
Related Documents :
23651916 - Sodium and nutrition labelling: a qualitative study exploring new zealand consumers' fo...
18467586 - Monte verde: seaweed, food, medicine, and the peopling of south america.
15484596 - 'unwilling' versus 'unable': chimpanzees' understanding of human intentional action.
14558786 - Metabolism of stevioside and rebaudioside a from stevia rebaudiana extracts by human mi...
8506236 - Food potentials of some unconventional oilseeds grown in nigeria--a brief review.
2061616 - Increased sensitivity of an enzyme-amplified colorimetric immunoassay for protein a-bea...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  202     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  277-80     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Queen Mary and Westfield College, London, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Colon / drug effects,  secretion*
Electric Stimulation
Humans
Intestinal Mucosa / drug effects,  metabolism*
Loperamide / pharmacology*
Morphine / pharmacology*
Muscle, Smooth / drug effects,  physiology
Norepinephrine / pharmacology
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 53179-11-6/Loperamide; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Putative role of endogenous insulin in cysteamine-induced hypersecretion of gastric acid in rats.
Next Document:  L-NG-nitro-arginine inhibits nicotine-induced relaxation of isolated rat duodenum.