Document Detail

Loperamide but not morphine has anti-secretory effects in human colon, in vitro.
MedLine Citation:
PMID:  1802746     Owner:  NLM     Status:  MEDLINE    
Isolated preparations of human colonic mucosa were set up in Ussing chambers. Noradrenaline reduced basal short-circuit current, morphine did not nor did loperamide except at the highest concentration tested. Electrically evoked increases in short-circuit current were unaffected by morphine but reduced by loperamide, by a naloxone-insensitive mechanism. Unidirectional fluxes of 22sodium and 36chloride were unaffected by morphine. It is concluded that loperamide but not morphine has an anti-secretory effect on human colonic mucosa.
D E Burleigh
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  202     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  277-80     Citation Subset:  IM    
Department of Pharmacology, Queen Mary and Westfield College, London, U.K.
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MeSH Terms
Colon / drug effects,  secretion*
Electric Stimulation
Intestinal Mucosa / drug effects,  metabolism*
Loperamide / pharmacology*
Morphine / pharmacology*
Muscle, Smooth / drug effects,  physiology
Norepinephrine / pharmacology
Reg. No./Substance:
51-41-2/Norepinephrine; 53179-11-6/Loperamide; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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